Hill M J, Kumar S, McTernan P G
Warwick Medical School, UK.
J Clin Pathol. 2009 Mar;62(3):206-11. doi: 10.1136/jcp.2007.049171.
This review summarises current experimental adipokine investigations and will focus on some of the procedures and techniques that are currently important in the clinical research laboratory. The complexity of measuring adipokines is discussed and the relative success of the various applications in the transition from the laboratory to clinical diagnosis assessed. In addition, as new adipokines continue to emerge, this review will consider the direction research is taking at the cutting edge of novel adipokine discovery. Finally, how a more comprehensive understanding of the pathobiology related to adipokines may enhance innovative therapeutic strategies designed to attenuate the predicted explosion in obesity related diseases will be discussed.
本综述总结了当前有关脂肪因子的实验研究，并将重点关注临床研究实验室中目前重要的一些程序和技术。文中讨论了测量脂肪因子的复杂性，并评估了各种应用在从实验室过渡到临床诊断过程中的相对成功率。此外，随着新的脂肪因子不断出现，本综述将探讨新型脂肪因子发现前沿的研究方向。最后，还将讨论如何更全面地理解与脂肪因子相关的病理生物学，可能会增强旨在减轻肥胖相关疾病预计激增的创新治疗策略。
