预测建模在合理重新设计生物系统中的作用。
The role of predictive modelling in rationally re-engineering biological systems.
作者信息
Koide Tie, Pang Wyming Lee, Baliga Nitin S
机构信息
Institute for Systems Biology, 1441 N 34th Street, Seattle, Washington 98103, USA.
出版信息
Nat Rev Microbiol. 2009 Apr;7(4):297-305. doi: 10.1038/nrmicro2107. Epub 2009 Mar 2.
Abstract
Technologies to synthesize and transplant a complete genome into a cell have opened limitless potential to redesign organisms for complex, specialized tasks. However, large-scale re-engineering of a biological circuit will require systems-level optimization that will come from a deep understanding of operational relationships among all the constituent parts of a cell. The integrated framework necessary for conducting such complex bioengineering requires the convergence of systems and synthetic biology. Here, we review the status of these rapidly developing interdisciplinary fields of biology and provide a perspective on plausible venues for their merger.
摘要
将完整基因组合成并移植到细胞中的技术，为重新设计生物体以执行复杂、特定任务开启了无限潜力。然而，生物回路的大规模重新设计需要系统层面的优化，而这将源于对细胞所有组成部分之间运作关系的深入理解。开展此类复杂生物工程所需的综合框架要求系统生物学和合成生物学相结合。在此，我们综述这些快速发展的生物学交叉领域的现状，并就它们可能的融合途径提供一种观点。
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