Shakya S, Dulal S, Maharjan I M
Department of Ophthalmology, Nepal Medical College, Attarkhel, Jorpati, Kathmandu, Nepal.
Nepal Med Coll J. 2008 Sep;10(3):147-50.
Pseudoexfoliation syndrome is an ocular condition characterized by a distinctive deposition of fibrillar material in the anterior segment of the eye. Pseudoexfoliation syndrome is frequently associated with glaucoma. Though it is seen in all the population, prevalence varies considerably in different races. A hospital based study done in Nepal by our group showed that Gurung population is frequently affected by this disease than any others. To determine the fact a larger population based study was necessary. Thus a research was designed to survey the various populations in the community. Different population from Kathmandu valley, Kavrepalanchowk, Pokhara, and Ghandruk were evaluated in two different phases to include major ethnic population living in Nepal. Household surveys done to bring all the targeted population to base hospital and detail examination including anterior segment evaluation after dilatation of pupil, optic disc evaluation, intraocular pressure measurement, gonioscopy, visual field recording and photographic documentation was done. Total of4430 population surveyed while only 2135 fulfilled the criteria for inclusion. Gurungs irrespective of their place of residence showed higher prevalence of Pseudoexfoliation syndrome accounting for 7.8% in Kathmandu valley while 12.0% in Ghandruk. Tamangs were affected very rarely by this disease accounting only for 0.3%. Gurungs are at higher risk of developing Pseudoexfoliation syndrome than any others in Nepal.
假性剥脱综合征是一种眼部疾病，其特征是在眼球前段有独特的纤维状物质沉积。假性剥脱综合征常与青光眼相关。虽然在所有人群中都可见到，但在不同种族中的患病率差异很大。我们团队在尼泊尔进行的一项基于医院的研究表明，古隆族比其他任何族群更容易患这种疾病。为了确定这一事实，有必要进行一项更大规模的基于人群的研究。因此，设计了一项研究来调查社区中的不同人群。来自加德满都谷地、卡夫雷巴兰乔克、博卡拉和甘杜克的不同人群在两个不同阶段接受了评估，以纳入生活在尼泊尔的主要族群。进行了家庭调查，将所有目标人群带到基地医院，并进行了详细检查，包括瞳孔散大后的前段评估、视盘评估、眼压测量、前房角镜检查、视野记录和摄影记录。总共调查了4430人，只有2135人符合纳入标准。无论居住地点如何，古隆族的假性剥脱综合征患病率都较高，在加德满都谷地占7.8%，在甘杜克占12.0%。塔芒族很少受这种疾病影响，仅占0.3%。在尼泊尔，古隆族比其他任何族群患假性剥脱综合征的风险都更高。
