Bhattacharyya D, Sur T K, Jana U, Debnath P K
Department of Pharmacology, Dr. B.C. Roy Institute of Post Graduate Medical Education and Research, 244B, Acharya J.C. Bose Road, Kolkata 700020, India.
Nepal Med Coll J. 2008 Sep;10(3):176-9.
Ocimumn sanctum, an Indian medicinal plant, has been on trial for its role in generalized anxiety disorder (GAD) in hospital based clinical set-up. Hamilton's brief psychiatric rating scale (BPRS) and thorough clinical investigations were used to screen the subjects. Thirty-five subjects (21 male and 14 female; average age 38.4 years) were medicated with the plant extract in a fixed dose regime (500 mg/capsule, twice daily, p.o. after meal). They were thoroughly investigated clinically and using standard questionnaires based on different psychological rating scale at baseline (day 0), mid-term (day 30) and final (day 60). The observations exhibited that, O. sanctum significantly (p<0.001) attenuated generalized anxiety disorders and also attenuated its correlated stress and depression. It further significantly (p<0.001) improved the willingness to adjustment and attention in human. Therefore, it may be concluded that O. sanctum may be useful in the treatment of GAD in human and may be a promising anxiolytic agent in near future.
圣罗勒，一种印度药用植物，已在医院临床环境中就其在广泛性焦虑症（GAD）中的作用进行试验。采用汉密尔顿简明精神病评定量表（BPRS）和全面的临床调查来筛选受试者。35名受试者（21名男性和14名女性；平均年龄38.4岁）按照固定剂量方案（500毫克/胶囊，每日两次，餐后口服）服用该植物提取物。在基线期（第0天）、中期（第30天）和末期（第60天），对他们进行了全面的临床调查，并使用基于不同心理评定量表的标准问卷进行评估。观察结果显示，圣罗勒显著（p<0.001）减轻了广泛性焦虑症，也减轻了与之相关的压力和抑郁。它还显著（p<0.001）提高了人类的适应意愿和注意力。因此，可以得出结论，圣罗勒可能对治疗人类的广泛性焦虑症有用，并且在不久的将来可能成为一种有前景的抗焦虑药物。
