Tao Ting, Wu Lin, Shen Bei-Bei, Zhao Yong-Ju
Department of Geriatrics, Shanghai Ruijin Hospital, Shanghai Jiaotong Medical University, Shanghai 200025, China.
Zhonghua Gan Zang Bing Za Zhi. 2009 Feb;17(2):120-3.
To study the abdominal adipose area, serum adiponectin and leptin levels of nonalcoholic fatty liver disease in elderly males.
A total of 238 elderly males (more than 60 years) were enrolled and divided into three groups: Nonalcoholic fatty liver disease (NAFLD) group (n = 76), matching group (age and body mass index matching with NAFLD group, n = 77), normal control group (n = 85). Serum levels of adiponectin and leptin were measured by RIA (radiological immunological assay). Abdominal adipose area was detected by computer tomography.
(1) body mass index (BMI), abdominal subcutaneous adipose area, visceral adipose area, total adipose area of NAFLD group and matching group were (26.87+/-2.62) kg/m2 and (26.63+/-1.97) kg/m2, (166.59+/-54.27) cm2 and (147.89+/-50.14) cm2, (148.94+/-53.72) cm2 and (150.06+/-45.47) cm2, (315.25+/-89.42) cm2 and (297.93+/-75.12) cm2, respectively; and were higher than those in control group (P less than 0.01). The abdominal subcutaneous adipose area is higher in NAFLD group than in matching group, however, the abdominal visceral adipose area and total adipose area were not significantly different between those two groups. (2) The serum leptin level in NAFLD group and matching group was significantly higher than that in control group, and serum leptin level was not significantly different between NAFLD group and matching group. The serum adiponectin of NAFLD group [(6.31+/-3.31)mug/ml] was significantly lower than that of matching group [(9.87+/-7.071)mug/ml, P less than 0.01] and control group (P less than 0.01). There was no difference in adiponectin level between matching group and control group. 3) AST, TG, abdominal subcutaneous adipose area, abdominal visceral adipose area were risk factors of NAFLD, while serum adiponectin was protective factor of NAFLD.
These data indicate that elderly male NAFLD patients manifest abdominal obesity, high serum leptin, low serum adiponecin, and suggest that adiponectin may play a crucial role in the pathogenesis of NAFLD in elderly males.
研究老年男性非酒精性脂肪性肝病患者的腹部脂肪面积、血清脂联素和瘦素水平。
纳入238例60岁以上老年男性，分为三组：非酒精性脂肪性肝病（NAFLD）组（n = 76）、匹配组（年龄和体重指数与NAFLD组匹配，n = 77）、正常对照组（n = 85）。采用放射免疫分析法（RIA）检测血清脂联素和瘦素水平。通过计算机断层扫描检测腹部脂肪面积。
（1）NAFLD组和匹配组的体重指数（BMI）、腹部皮下脂肪面积、内脏脂肪面积、总脂肪面积分别为（26.87±2.62）kg/m²和（26.63±1.97）kg/m²、（166.59±54.27）cm²和（147.89±50.14）cm²、（148.94±53.72）cm²和（150.06±45.47）cm²、（315.25±89.42）cm²和（297.93±75.12）cm²；均高于对照组（P＜0.01）。NAFLD组的腹部皮下脂肪面积高于匹配组，然而，两组的腹部内脏脂肪面积和总脂肪面积无显著差异。（2）NAFLD组和匹配组的血清瘦素水平显著高于对照组，且NAFLD组与匹配组的血清瘦素水平无显著差异。NAFLD组的血清脂联素[（6.31±3.31）μg/ml]显著低于匹配组[（9.87±7.071）μg/ml，P＜0.01]和对照组（P＜0.01）。匹配组与对照组的脂联素水平无差异。（3）谷草转氨酶（AST）、甘油三酯（TG）、腹部皮下脂肪面积、腹部内脏脂肪面积是NAFLD的危险因素，而血清脂联素是NAFLD的保护因素。
这些数据表明老年男性NAFLD患者表现为腹部肥胖、血清瘦素水平高、血清脂联素水平低，提示脂联素可能在老年男性NAFLD的发病机制中起关键作用。
