迈向果蝇基因组的克隆与图谱绘制。
Toward cloning and mapping the genome of Drosophila.
作者信息
Merriam J, Ashburner M, Hartl D L, Kafatos F C
机构信息
Department of Biology, University of California, Los Angeles 90024.
出版信息
Science. 1991 Oct 11;254(5029):221-5. doi: 10.1126/science.254.5029.221.
PMID:1925579
Abstract
An ultimate goal of Drosophila genetics is to identify and define the functions of all the genes in the organism. Traditional approaches based on the isolation of mutant genes have been extraordinary fruitful. Recent advances in the manipulation and analysis of large DNA fragments have made it possible to develop detailed molecular maps of the Drosophila genome as the initial steps in determining the complete DNA sequence.
摘要
果蝇遗传学的一个最终目标是识别并确定该生物体中所有基因的功能。基于突变基因分离的传统方法已经取得了极其丰硕的成果。在大片段DNA操作与分析方面的最新进展，使得绘制果蝇基因组的详细分子图谱成为可能，这是确定完整DNA序列的初步步骤。
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