通过捕获和释放胺的金纳米颗粒实现光调节的细胞信号激活。

Light-regulated activation of cellular signaling by gold nanoparticles that capture and release amines.

作者信息

Nakanishi Jun, Nakayama Hidekazu, Shimizu Takahiro, Ishida Haruhisa, Kikuchi Yukiko, Yamaguchi Kazuo, Horiike Yasuhiro

机构信息

World Premier International Research Center Initiative, International Center for Materials Nanoarchitectonics, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.

出版信息

J Am Chem Soc. 2009 Mar 25;131(11):3822-3. doi: 10.1021/ja809236a.

DOI:10.1021/ja809236a

PMID:19256545

Abstract

A photoresponsive nanocarrier for amines based on gold nanoparticles (GNPs) having a photocleavable succinimidyl ester has been developed. It offers a useful platform for the synthesis of caged compounds. Using the GNPs, we have developed caged histamine for the first time and applied it to evoke intracellular signaling by controlled near-UV irradiation. The present work will allow for new possibilities in studies of inter- and intracellular signaling networks.

摘要

一种基于具有可光裂解琥珀酰亚胺酯的金纳米颗粒（GNP）的胺类光响应纳米载体已被开发出来。它为笼形化合物的合成提供了一个有用的平台。利用这些金纳米颗粒，我们首次开发出了笼形组胺，并将其应用于通过可控近紫外照射引发细胞内信号传导。目前的工作将为细胞间和细胞内信号网络的研究带来新的可能性。