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Inorganic Nanoparticles for Therapeutic Delivery: Trials, Tribulations and Promise.用于治疗递送的无机纳米颗粒:试验、困境与前景。
Curr Opin Colloid Interface Sci. 2014 Apr 1;19(2):49-55. doi: 10.1016/j.cocis.2014.03.004.
2
Recent advancements in biocompatible inorganic nanoparticles towards biomedical applications.生物相容的无机纳米粒子在生物医学应用方面的最新进展。
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The gold standard: gold nanoparticle libraries to understand the nano-bio interface.金标准:金纳米粒子文库以了解纳米 - 生物界面。
Acc Chem Res. 2013 Mar 19;46(3):650-61. doi: 10.1021/ar300015b. Epub 2012 Jun 25.
4
Inorganic Nanoparticles for Cancer Therapy: A Transition from Lab to Clinic.无机纳米粒子在癌症治疗中的应用:从实验室到临床的转变。
Curr Med Chem. 2018;25(34):4269-4303. doi: 10.2174/0929867325666171229141156.
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Inorganic nanosystems for therapeutic delivery: status and prospects.无机纳米系统用于治疗性递药:现状与展望。
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In vivo bio-safety evaluations and diagnostic/therapeutic applications of chemically designed mesoporous silica nanoparticles.化学设计的介孔硅纳米粒子的体内生物安全性评估和诊断/治疗应用。
Adv Mater. 2013 Jun 18;25(23):3144-76. doi: 10.1002/adma.201205292. Epub 2013 May 17.
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Encapsulation of Inorganic Nanomaterials inside Virus-Based Nanoparticles for Bioimaging.用于生物成像的基于病毒的纳米颗粒内无机纳米材料的封装
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Chem Rev. 2017 Nov 22;117(22):13461-13501. doi: 10.1021/acs.chemrev.7b00231. Epub 2017 Oct 19.
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Multifunctional Drug Delivery Systems Using Inorganic Nanomaterials: A Review.使用无机纳米材料的多功能药物递送系统:综述
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Functional DNA-containing nanomaterials: cellular applications in biosensing, imaging, and targeted therapy.含功能性DNA的纳米材料:在生物传感、成像和靶向治疗中的细胞应用
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Surface Functionalization of Nanocarriers with Anti-EGFR Ligands for Cancer Active Targeting.用于癌症主动靶向的抗表皮生长因子受体(EGFR)配体修饰纳米载体的表面功能化
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Biomedical Applications of Lanthanide Nanomaterials, for Imaging, Sensing and Therapy.镧系纳米材料在医学成像、传感和治疗中的生物医学应用。
Nanotheranostics. 2022 Jan 1;6(2):184-194. doi: 10.7150/ntno.65530. eCollection 2022.
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Nano Today. 2020 Oct;34. doi: 10.1016/j.nantod.2020.100914. Epub 2020 Jul 2.
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One-year chronic toxicity evaluation of single dose intravenously administered silica nanoparticles in mice and their Ex vivo human hemocompatibility.小鼠单次静脉注射二氧化硅纳米颗粒的一年期慢性毒性评估及其体外人血液相容性
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Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes.靶向 microRNAs 作为一种治疗策略,以减少糖尿病中的氧化应激。
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NaCl Nanoparticles as a Cancer Therapeutic.氯化钠纳米颗粒作为一种癌症治疗方法。
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Subchronic and chronic toxicity evaluation of inorganic nanoparticles for delivery applications.用于递药应用的无机纳米颗粒的亚慢性和慢性毒性评价。
Adv Drug Deliv Rev. 2019 Apr;144:112-132. doi: 10.1016/j.addr.2019.07.006. Epub 2019 Jul 8.
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Recent trends in CRISPR-Cas system: genome, epigenome, and transcriptome editing and CRISPR delivery systems.CRISPR-Cas系统的最新趋势:基因组、表观基因组和转录组编辑以及CRISPR递送系统
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Hybrid, metal oxide-peptide amphiphile micelles for molecular magnetic resonance imaging of atherosclerosis.用于动脉粥样硬化的分子磁共振成像的杂化、金属氧化物-肽两亲胶束。
J Nanobiotechnology. 2018 Nov 15;16(1):92. doi: 10.1186/s12951-018-0420-8.
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Biomimetically engineered Amphotericin B nano-aggregates circumvent toxicity constraints and treat systemic fungal infection in experimental animals.仿生工程化两性霉素 B 纳米聚集体规避了毒性限制,可治疗实验动物的系统性真菌感染。
Sci Rep. 2017 Sep 19;7(1):11873. doi: 10.1038/s41598-017-11847-0.

本文引用的文献

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Protein coronas suppress the hemolytic activity of hydrophilic and hydrophobic nanoparticles.蛋白质冠层可抑制亲水性和疏水性纳米颗粒的溶血活性。
Mater Horiz. 2014 Jan 1;1(1):102-105. doi: 10.1039/C3MH00075C.
2
Multidentate zwitterionic ligands provide compact and highly biocompatible quantum dots.多齿两性离子配体提供了紧凑且高度生物相容的量子点。
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Protein corona significantly reduces active targeting yield.蛋白质冠显著降低了主动靶向的效果。
Chem Commun (Camb). 2013 Mar 28;49(25):2557-9. doi: 10.1039/c3cc37307j.
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Combining ligand design with photoligation to provide compact, colloidally stable, and easy to conjugate quantum dots.将配体设计与光连接相结合,提供紧凑、胶体稳定且易于共轭的量子点。
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Radioluminescent gold nanocages with controlled radioactivity for real-time in vivo imaging.具有放射性控制的放射光金纳米笼,用于实时活体成像。
Nano Lett. 2013 Feb 13;13(2):581-5. doi: 10.1021/nl304111v. Epub 2013 Feb 1.
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Single-walled carbon nanotube surface control of complement recognition and activation.单壁碳纳米管表面控制补体的识别与激活。
ACS Nano. 2013 Feb 26;7(2):1108-19. doi: 10.1021/nn3055175. Epub 2013 Jan 16.
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Biomolecular coronas provide the biological identity of nanosized materials.生物分子冠赋予纳米材料生物身份。
Nat Nanotechnol. 2012 Dec;7(12):779-86. doi: 10.1038/nnano.2012.207.
8
Near infrared light triggered release of biomacromolecules from hydrogels loaded with upconversion nanoparticles.近红外光触发载上转换纳米粒子水凝胶中生物大分子的释放。
J Am Chem Soc. 2012 Oct 10;134(40):16558-61. doi: 10.1021/ja308876j. Epub 2012 Sep 28.
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Surface functionality of nanoparticles determines cellular uptake mechanisms in mammalian cells.纳米颗粒的表面功能决定了哺乳动物细胞的细胞摄取机制。
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(α-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging.(α-NaYbF4:Tm(3+))/CaF2 核/壳纳米粒子具有高效的近红外到近红外上转换性能,可用于高对比度的深层组织生物成像。
ACS Nano. 2012 Sep 25;6(9):8280-7. doi: 10.1021/nn302972r. Epub 2012 Sep 4.

用于治疗递送的无机纳米颗粒:试验、困境与前景。

Inorganic Nanoparticles for Therapeutic Delivery: Trials, Tribulations and Promise.

作者信息

Tonga Gulen Yesilbag, Moyano Daniel F, Kim Chang Soo, Rotello Vincent M

机构信息

Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA, 01003, USA.

出版信息

Curr Opin Colloid Interface Sci. 2014 Apr 1;19(2):49-55. doi: 10.1016/j.cocis.2014.03.004.

DOI:10.1016/j.cocis.2014.03.004
PMID:24955019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4061753/
Abstract

Inorganic nanomaterials have a wide array of physical and structural properties that make them attractive candidates for imaging and therapeutic delivery. Nanoparticle platforms have been intensely studied for these applications, and examples are starting to enter the clinic. This review looks at why inorganic particles provide promising platforms for biomedicine, and what issues need to be addressed for them to reach their potential.

摘要

无机纳米材料具有广泛的物理和结构特性,这使其成为成像和治疗递送方面颇具吸引力的候选材料。纳米颗粒平台已针对这些应用展开了深入研究,并且一些实例已开始进入临床阶段。本综述探讨了为何无机颗粒为生物医学提供了有前景的平台,以及要发挥其潜力还需要解决哪些问题。