Kim Chang Soo, Duncan Bradley, Creran Brian, Rotello Vincent M
Department of Chemistry, University of Massachusetts, Amherst, MA 01003 USA.
Nano Today. 2013 Aug 1;8(4):439-447. doi: 10.1016/j.nantod.2013.07.004.
Drug delivery systems (DDSs) face several challenges including site-specific delivery, stability, and the programmed release of drugs. Engineered nanoparticle (NP) surfaces with responsive moieties can enhance the efficacy of DDSs for and systems. This triggering process can be achieved through both endogenous (biologically controlled release) and exogenous (external stimuli controlled release) activation. In this review, we will highlight recent examples of the use of triggered release strategies of engineered nanomaterials for and applications.
药物递送系统（DDSs）面临着几个挑战，包括特定部位递送、稳定性和药物的程序释放。具有响应部分的工程化纳米颗粒（NP）表面可以提高DDSs在[具体应用领域1]和[具体应用领域2]系统中的功效。这种触发过程可以通过内源性（生物控制释放）和外源性（外部刺激控制释放）激活来实现。在这篇综述中，我们将重点介绍工程化纳米材料触发释放策略在[具体应用领域1]和[具体应用领域2]应用中的最新实例。
