Khovidhunkit Siribang-on P, Buajeeb Waranun, Sanguansin Sirima, Poomsawat Sopee, Weerapradist Woranut
Department of Hospital Dentistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
Asian Pac J Cancer Prev. 2008 Oct-Dec;9(4):771-5.
Although tobacco, alcohol abuse and betel nut chewing habit are well recognized risk factors for oral squamous cell carcinoma (OSCC), there is evidence to indicate that human papillomavirus (HPV) may also play some inducing role. The purpose of this study was to investigate the presence of HPV in Thai patients with oral squamous cell carcinoma, leukoplakia and lichen planus using the polymerase chain reaction (PCR). Biopsies of oral squamous cell carcinoma, leukoplakia and lichen planus were obtained from 65 patients, 15 males and 50 females, aged between 30- 88 years old. Extracted DNA was evaluated for HPV infections by PCR analysis using consensus primers specific for L1 region of HPV. Only one sample (1.54%) was positive, suggesting that HPV may not play an important role in this group of Thai patients.
尽管烟草、酗酒和嚼槟榔习惯是口腔鳞状细胞癌（OSCC）公认的危险因素，但有证据表明人乳头瘤病毒（HPV）可能也起一定的诱发作用。本研究的目的是使用聚合酶链反应（PCR）调查泰国口腔鳞状细胞癌、白斑病和扁平苔藓患者中HPV的存在情况。从65例患者（年龄在30至88岁之间，15例男性和50例女性）获取口腔鳞状细胞癌、白斑病和扁平苔藓的活检样本。使用针对HPV L1区域的共有引物，通过PCR分析评估提取的DNA是否存在HPV感染。仅一个样本（1.54%）呈阳性，这表明HPV在这组泰国患者中可能不起重要作用。
