Solov'yov Andrey V, Surdutovich Eugene, Scifoni Emanuele, Mishustin Igor, Greiner Walter
Frankfurt Institute for Advanced Studies, Ruth-Moufang-Strasse 1, 60438 Frankfurt am Main, Germany.
Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Jan;79(1 Pt 1):011909. doi: 10.1103/PhysRevE.79.011909. Epub 2009 Jan 15.
We propose a multiscale approach to understand the physics related to ion-beam cancer therapy. It allows the calculation of the probability of DNA damage as a result of irradiation of tissues with energetic ions, up to 430 MeV/u. This approach covers different scales, starting from the large scale, defined by the ion stopping, followed by a smaller scale, defined by secondary electrons and radicals, and ending with the shortest scale, defined by interactions of secondaries with the DNA. We present calculations of the probabilities of single and double strand breaks of DNA, suggest a way to further expand such calculations, and also make some estimates for glial cells exposed to radiation.
我们提出一种多尺度方法来理解与离子束癌症治疗相关的物理学。它能够计算用能量高达430 MeV/u的高能离子照射组织导致DNA损伤的概率。这种方法涵盖了不同的尺度，从由离子阻止定义的大尺度开始，接着是由二次电子和自由基定义的较小尺度，最后以由二次粒子与DNA的相互作用定义的最短尺度结束。我们给出了DNA单链和双链断裂概率的计算结果，提出了进一步扩展此类计算的方法，并且还对暴露于辐射的神经胶质细胞进行了一些估算。
