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对伊曲康唑和伏立康唑均耐药的禽烟曲霉菌株。

Avian Aspergillus fumigatus strains resistant to both itraconazole and voriconazole.

作者信息

Beernaert L A, Pasmans F, Van Waeyenberghe L, Dorrestein G M, Verstappen F, Vercammen F, Haesebrouck F, Martel A

机构信息

Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.

出版信息

Antimicrob Agents Chemother. 2009 May;53(5):2199-201. doi: 10.1128/AAC.01492-08. Epub 2009 Mar 2.

Abstract

The in vitro susceptibilities of 59 avian Aspergillus fumigatus strains to amphotericin B, itraconazole, and voriconazole were determined using the standard microdilution broth method (CLSI M38-A2). Four isolates showed acquired resistance to itraconazole and voriconazole, harboring implications for the treatment of aspergillosis in both birds and humans.

摘要

采用标准微量稀释肉汤法(CLSI M38 - A2)测定了59株禽烟曲霉对两性霉素B、伊曲康唑和伏立康唑的体外敏感性。4株分离株对伊曲康唑和伏立康唑表现出获得性耐药,这对鸟类和人类曲霉病的治疗都有影响。

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