肌萎缩侧索硬化症中的局部肌肉阻抗异常
Localized muscle impedance abnormalities in amyotrophic lateral sclerosis.
作者信息
Tarulli Andrew W, Garmirian Lindsay P, Fogerson Patricia M, Rutkove Seward B
机构信息
From the Division of Neuromuscular Diseases, Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.
出版信息
J Clin Neuromuscul Dis. 2009 Mar;10(3):90-6. doi: 10.1097/CND.0b013e3181934423.
Abstract
OBJECTIVES
To assess changes in electrical impedance myography (EIM) parameters in amyotrophic lateral sclerosis (ALS).
METHODS
Ten patients with ALS and a cohort of normal subjects underwent EIM testing of tibialis anterior. Montages using voltage and current electrodes placed at a distance (far) and in close proximity (near) were compared. The EIM parameters, resistance (R), reactance (X), and phase (theta) in the patients with ALS, were compared with normal values.
RESULTS
theta measured at 50 kHz using the near montage was most sensitive to the presence of ALS, with 9 of 10 patients with ALS having smaller theta values than the calculated lower limit of normal. theta using the far montage and X using both the near and far montages were also sensitive to disease, whereas R did not seem to be useful.
CONCLUSION
EIM is sensitive to muscle abnormalities in ALS, with theta measured with near montages providing the best results.
摘要
目的
评估肌萎缩侧索硬化症（ALS）患者的电阻抗肌电图（EIM）参数变化。
方法
对10例ALS患者和一组正常受试者进行胫前肌的EIM测试。比较使用相距较远（远）和紧邻（近）放置的电压和电流电极的导联组合。将ALS患者的EIM参数，即电阻（R）、电抗（X）和相位（θ）与正常值进行比较。
结果
使用近导联组合在50 kHz时测量的θ对ALS的存在最为敏感，10例ALS患者中有9例的θ值低于计算出的正常下限。使用远导联组合测量的θ以及使用近、远导联组合测量的X对疾病也敏感，而R似乎没有用处。
结论
EIM对ALS患者的肌肉异常敏感，使用近导联组合测量的θ提供的结果最佳。
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