Coker Ann L, Eggleston Katherine S, Du Xianglin L, Ramondetta Lois
School of Medicine, University of Kentucky, Lexington, KY, USA.
Int J Gynecol Cancer. 2009 Jan;19(1):13-20. doi: 10.1111/IGC.0b013e318197f343.
To determine predictors of cervical cancer survival by socioeconomic status (SES), urbanization, race/ethnicity, comorbid conditions, and treatment among elderly Medicare-eligible women whose conditions were diagnosed with cervical cancer in a multiethnic population.
: A total of 538 women with cervical cancer aged 65 years or older were identified from 1999 to 2001 from the Texas Cancer Registry and were linked with the state Medicare data and Texas Vital Records to determine survival times. All women had similar access to care through Medicare fee-for-services insurance. A composite measure of SES was created using census tract-level data as was urbanization. Treatment and comorbid conditions were available from the Medicare data. Cox proportional hazards modeling was used for all-cause and cervical cancer-specific survival analysis.
: Increased age (P < 0.0001) and advanced tumor stage (P < 0.0001) were associated with poorer all-cause and cervical cancer-specific survival. Having a comorbid condition was associated with all-cause survival (P < 0.01) but not cervical cancer-specific mortality. After adjusting for confounders, women receiving some form of treatment were almost half as likely to die with cervical cancer (adjusted hazard ratio = 0.68; 95% confidence interval, 0.52-0.89). After adjustment for all confounders, Hispanic women consistently had lower all-cause and cervical cancer-specific mortality rates relative to non-Hispanic white and non-Hispanic black women.
: Among women with similar health care coverage, Hispanic women had consistently lower all-cause and cervical cancer-specific mortality rates than other older women whose conditions were diagnosed with this disease in Texas. The presence of comorbid conditions and treatment were important predictors of survival, yet these factors do not explain the survival advantage for Hispanic women.
为了确定在一个多民族人群中,符合老年医疗保险条件且被诊断患有宫颈癌的女性,其社会经济地位(SES)、城市化程度、种族/民族、合并症以及治疗情况对宫颈癌生存的预测因素。
1999年至2001年期间,从德克萨斯癌症登记处识别出538名年龄在65岁及以上的宫颈癌女性,并将其与该州的医疗保险数据和德克萨斯州生命记录相联系,以确定生存时间。所有女性通过医疗保险按服务收费保险获得相似的医疗服务。使用人口普查区层面的数据创建了SES综合指标以及城市化指标。医疗保险数据提供了治疗和合并症情况。采用Cox比例风险模型进行全因生存分析和宫颈癌特异性生存分析。
年龄增加(P<0.0001)和肿瘤分期较晚(P<0.0001)与较差的全因生存和宫颈癌特异性生存相关。患有合并症与全因生存相关(P<0.01),但与宫颈癌特异性死亡率无关。在调整混杂因素后,接受某种形式治疗的女性死于宫颈癌的可能性几乎减半(调整后的风险比=0.68;95%置信区间,0.52-0.89)。在调整所有混杂因素后,西班牙裔女性相对于非西班牙裔白人女性和非西班牙裔黑人女性,全因死亡率和宫颈癌特异性死亡率始终较低。
在医疗保健覆盖相似的女性中,西班牙裔女性的全因死亡率和宫颈癌特异性死亡率始终低于德克萨斯州其他被诊断患有这种疾病的老年女性。合并症的存在和治疗是生存的重要预测因素,但这些因素并不能解释西班牙裔女性的生存优势。