Chen Yueli, Vuong Laurel N, Liu Jonathan, Ho Joseph, Srinivasan Vivek J, Gorczynska Iwona, Witkin Andre J, Duker Jay S, Schuman Joel, Fujimoto James G
Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Opt Express. 2009 Mar 2;17(5):4046-60. doi: 10.1364/oe.17.004046.
Ultrahigh resolution optical coherence tomography (OCT) enhances the ability to visualize different intra retinal layers. In age-related macular degeneration (AMD), pathological changes in individual retinal layers, including photoreceptor inner and outer segments and retinal pigment epithelium, can be detected. OCT using spectral / Fourier domain detection enables high speed, volumetric imaging of the macula, which provides comprehensive three-dimensional tomographic and morphologic information. We present a case series of AMD patients, from mild drusen to more advanced geographic atrophy and exudative AMD. Patients were imaged with a research prototype, ultrahigh resolution spectral / Fourier domain OCT instrument with 3.5 microm axial image resolution operating at 25,000 axial scans per second. These cases provide representative volumetric datasets of well-documented AMD pathologies which could be used for the development of visualization and imaging processing methods and algorithms.
超高分辨率光学相干断层扫描（OCT）增强了可视化视网膜各层的能力。在年龄相关性黄斑变性（AMD）中，可以检测到视网膜各层的病理变化，包括光感受器内、外节以及视网膜色素上皮。使用光谱/傅里叶域检测的OCT能够对黄斑进行高速容积成像，提供全面的三维断层扫描和形态学信息。我们展示了一系列AMD患者的病例，从轻度玻璃膜疣到更晚期的地图样萎缩和渗出性AMD。患者使用一台研究原型超高分辨率光谱/傅里叶域OCT仪器进行成像检查，该仪器轴向图像分辨率为3.5微米，每秒进行25000次轴向扫描。这些病例提供了有充分记录的AMD病变的代表性容积数据集，可用于可视化和图像处理方法及算法的开发。
