Littlejohns P, Baveystock C M, Parnell H, Jones P W
Department of Public Health Sciences, St George's Hospital Medical School, London.
Thorax. 1991 Aug;46(8):559-64. doi: 10.1136/thx.46.8.559.
A randomised controlled trial was undertaken to determine whether a respiratory health worker was effective in reducing the respiratory impairment, disability, and handicap experienced by patients with chronic airflow limitation attending a respiratory outpatient department. The 152 adults (aged 30-75 years) who participated had a prebronchodilator forced expiratory volume in one second (FEV1) below 60% predicted and no other disease. They were randomised to receive the care of a respiratory health worker or the normal services provided by the outpatient department. The respiratory health worker provided health education and symptom and treatment monitoring in liaison with primary care services. After one year there was little difference between the two groups in spirometric values (FEV1 and forced vital capacity before and after salbutamol 200 micrograms), disability (six minute walking distance and paced step test), and handicap (sickness impact profile, hospital anxiety and depression scale). Patients not looked after by the respiratory health worker were more likely to die (relative risk 2.9 (95% confidence limits 0.8, 10.2); when age and FEV1 were controlled for this risk increased to 5.5 (95% confidence limits 1.2, 24.5). Patients looked after by the respiratory health worker attended their general practitioner more frequently and were prescribed a greater range of drugs. This is the third study to have found limited measurable benefit in terms of morbidity from the intervention of a respiratory health worker. This may be due to the ability of such workers to keep frail patients alive.
一项随机对照试验旨在确定呼吸健康工作者是否能有效减轻在呼吸科门诊就诊的慢性气流受限患者所经历的呼吸功能损害、残疾和障碍。参与试验的152名成年人(年龄在30 - 75岁之间),其支气管扩张剂前一秒用力呼气量(FEV1)低于预测值的60%,且无其他疾病。他们被随机分配接受呼吸健康工作者的护理或门诊提供的常规服务。呼吸健康工作者与基层医疗服务机构联络,提供健康教育以及症状和治疗监测。一年后,两组在肺功能指标(FEV1以及使用200微克沙丁胺醇前后的用力肺活量)、残疾程度(六分钟步行距离和定速步测)和障碍程度(疾病影响量表、医院焦虑抑郁量表)方面几乎没有差异。未由呼吸健康工作者护理的患者死亡可能性更高(相对风险为2.9(95%置信区间0.8, 10.2);在控制年龄和FEV1后,此风险增加至5.5(95%置信区间1.2, 24.5)。由呼吸健康工作者护理的患者更频繁地就诊于全科医生,并且被开具的药物种类更多。这是第三项发现呼吸健康工作者的干预在发病率方面的可测量益处有限的研究。这可能是由于这类工作者有能力维持体弱患者的生命。