Jones P W, Baveystock C M, Littlejohns P
Division of Physiological Medicine, St George's Hospital Medical School, London, UK.
Am Rev Respir Dis. 1989 Dec;140(6):1538-43. doi: 10.1164/ajrccm/140.6.1538.
The relationship between general health measured using the Sickness Impact Profile (SIP), lung spirometry, arterial oxygen saturation during exercise, and six-minute walking distance was studied in 141 patients with chronic airflow limitation. In addition the patients completed the Hospital Anxiety and Depression Questionnaire and the Medical Research Council (MRC) Bronchitis Questionnaire. Their mean age was 63 years (range 31 to 75) and their mean FEV1 was 47 +/- 23 (SD)% of predicted normal. The SIP scores were lower (i.e., the patients had better general health) than in previously reported patients who had greater physiological disturbance, but the profile of the different category scores within the SIP was similar to previous findings. Walking distance correlated with the SIP better than any spirometric measure or arterial saturation and accounted for 41% of the variance in SIP (p less than 0.001). The SIP score was considerably higher in patients who wheezed every day compared with those who did not (p less than 0.005). In patients who reported that their breathing was not normal between acute attacks of breathlessness and wheeze, the SIP score was twice as high as in those who felt normal between attacks (p less than 0.0006). Walking distance, depression score, and MRC dyspnea score correlated with SIP score independently of each other. A multiple regression incorporating these three variables accounted for 62% of the total variance in SIP score. Age, sex, and response to bronchodilator were not correlated with SIP score. We conclude that the SIP provides a valid measure of general health in a population of patients with chronic airflow limitation.
在141例慢性气流受限患者中，研究了使用疾病影响量表（SIP）测量的总体健康状况、肺功能测定、运动期间动脉血氧饱和度和6分钟步行距离之间的关系。此外，患者还完成了医院焦虑和抑郁问卷以及医学研究委员会（MRC）支气管炎问卷。他们的平均年龄为63岁（范围31至75岁），平均第一秒用力呼气容积（FEV1）为预测正常值的47±23（标准差）%。与先前报道的生理紊乱更严重的患者相比，SIP评分更低（即患者总体健康状况更好），但SIP内不同类别评分的概况与先前的研究结果相似。步行距离与SIP的相关性优于任何肺功能测量指标或动脉血氧饱和度，并且占SIP变异的41%（p<0.001）。与不每天喘息的患者相比，每天喘息的患者SIP评分显著更高（p<0.005）。在报告在急性呼吸急促和喘息发作之间呼吸不正常的患者中，SIP评分是在发作之间感觉正常的患者的两倍（p<0.0006）。步行距离、抑郁评分和MRC呼吸困难评分彼此独立地与SIP评分相关。纳入这三个变量的多元回归占SIP评分总变异的62%。年龄、性别和对支气管扩张剂的反应与SIP评分无关。我们得出结论，SIP为慢性气流受限患者群体的总体健康状况提供了一种有效的测量方法。
