[黄芪四君子汤胶囊指纹图谱峰与其相关药材的相关性]
[Correlativity between fingerprint peaks of HQSM capsule and its relevant herbs].
作者信息
Chen Jian-zhen, Lv Gui-yuan, Chen Su-hong, Ye Lei
机构信息
Zhejiang Chinese Medical University, Hangzhou 310053, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(23):2768-71.
OBJECTIVE
To establish HPLC fingerprint of HQSM capsules,and a new method for correlativity analysis between fingerprint peaks of HQSM and its relevant herbs based on the fingerprint analysis.
METHOD
The chromatographic fingerprints of HQSM and its relevant herbs were analyzed by HPLC configured with DAD. The similarity of the HPLC fingerprints between HQSM and its relevant herbs and the comparison of UV spectra of the main peaks in both of fingerprints were used as indices to evaluate the correlativity.
RESULT
The HPLC fingerprint with 16 common peaks was established and the chromatographic peaks were determined.
CONCLUSION
The established method effectively controlled the quality of HQSM and establised the correlativity between HQSM and its relevant herbs, which would contribute to deduce the chemical components or sources of traditional Chinese medicine prescription.
目的
建立黄芪生脉胶囊的高效液相色谱指纹图谱，并基于指纹图谱分析建立黄芪生脉与其相关药材指纹图谱峰之间相关性分析的新方法。
方法
采用配有二极管阵列检测器（DAD）的高效液相色谱法分析黄芪生脉及其相关药材的色谱指纹图谱。以黄芪生脉与其相关药材的高效液相色谱指纹图谱相似度及两者指纹图谱中主要峰的紫外光谱比较为指标评估相关性。
结果
建立了具有16个共有峰的高效液相色谱指纹图谱并确定了色谱峰。
结论
所建立的方法有效控制了黄芪生脉的质量，建立了黄芪生脉与其相关药材之间的相关性，这将有助于推断中药复方的化学成分或来源。
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