Yotphan Sirilata, Bergman Robert G, Ellman Jonathan A
Department of Chemistry, University of California and Division of Chemical Sciences, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Org Lett. 2009 Apr 2;11(7):1511-4. doi: 10.1021/ol900103a.
A method for the direct arylation of benzotriazepines is reported, employing an aryl iodide as the coupling partner, copper iodide as the catalyst, and lithium tert-butoxide as the base. A variety of electron-rich, electron-poor, and sterically hindered aryl iodides are compatible with the reaction conditions. The arylation reaction can also be performed outside a glovebox in air without a significant decrease in yield. Furthermore, convenient microwave conditions for carrying out this transformation are reported.
报道了一种苯并三氮杂卓直接芳基化的方法，该方法使用芳基碘作为偶联配偶体、碘化铜作为催化剂、叔丁醇锂作为碱。多种富电子、缺电子和空间位阻较大的芳基碘与反应条件兼容。芳基化反应也可以在手套箱外的空气中进行，产率不会显著降低。此外，还报道了进行这种转化的便捷微波条件。
