通过苯炔中间体实现的基于基底的 sp2 C-H 键的分子间芳基化反应。
Base-mediated intermolecular sp2 C-H bond arylation via benzyne intermediates.
机构信息
Department of Chemistry, University of Houston, Houston, Texas 77204-5003, USA.
出版信息
J Am Chem Soc. 2011 Mar 30;133(12):4243-5. doi: 10.1021/ja200184b. Epub 2011 Mar 8.
Abstract
A transition-metal-free method for arylation of heterocycle and arene carbon-hydrogen bonds by aryl chlorides and fluorides has been developed. The reactions proceed via aryne intermediates and are highly regioselective with respect to the C-H bond coupling component.
摘要
发展了一种无过渡金属的芳基氯和氟对杂环和芳烃碳氢键芳基化方法。这些反应通过芳炔中间体进行，并且对于 C-H 键偶联组分具有高度的区域选择性。
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