来自淡水蓝藻铜绿微囊藻（NIES-100）的微肽菌素
Micropeptins from the freshwater cyanobacterium Microcystis aeruginosa (NIES-100).
作者信息
Kisugi Takaya, Okino Tatsufumi
机构信息
Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan.
出版信息
J Nat Prod. 2009 Apr;72(4):777-81. doi: 10.1021/np800631t.
PMID:19260658
Abstract
Micropeptins C (1), D (2), E (3), and F (4) have been isolated from the freshwater cyanobacterium Microcystis aeruginosa (NIES-100). The structures were elucidated by analyses of MS, NMR spectra, and chemical degradation. Micropeptins C, D, E, and F inhibited chymotrypsin with IC(50)'s of 1.1, 1.2, 1.0, and 1.5 microg/mL, respectively.
摘要
微肽素C（1）、D（2）、E（3）和F（4）是从淡水蓝藻铜绿微囊藻（NIES-100）中分离得到的。通过质谱、核磁共振光谱分析和化学降解对其结构进行了阐明。微肽素C、D、E和F对胰凝乳蛋白酶具有抑制作用，其半数抑制浓度（IC50）分别为1.1、1.2、1.0和1.5微克/毫升。
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