白细胞介素-17可增加JEG-3人绒毛膜癌细胞的孕酮分泌。
Interleukin-17 increased progesterone secretion by JEG-3 human choriocarcinoma cells.
作者信息
Pongcharoen Sutatip, Supalap Kwansuda
机构信息
Department of Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand.
出版信息
Am J Reprod Immunol. 2009 Apr;61(4):261-4. doi: 10.1111/j.1600-0897.2009.00693.x.
PROBLEM
JEG-3 choriocarcinoma cell line has previously been reported to express a receptor for interleukin (IL)-17. The involvement of IL-17 in the production of progesterone and human chorionic gonadotropin by placental trophoblast has not been investigated.
METHOD OF STUDY
The present study investigated the in vitro effect of IL-17 on progesterone and human chorionic gonadotropin (hCG) secretion by JEG-3 cells. Both hormones were quantified using enzyme-linked immunosorbent assays.
RESULTS
The results showed that IL-17 significantly increased progesterone secretion at 6 (P < 0.001) and 24 (P < 0.01) hr, while this cytokine had no effect on hCG secretion.
CONCLUSION
Interleukin-17 may regulate the function of JEG-3 cells through increased progesterone secretion.
问题
先前有报道称JEG - 3绒毛膜癌细胞系表达白细胞介素（IL）-17受体。白细胞介素-17在胎盘滋养层细胞产生孕酮和人绒毛膜促性腺激素中的作用尚未得到研究。
研究方法
本研究调查了白细胞介素-17对JEG - 3细胞分泌孕酮和人绒毛膜促性腺激素（hCG）的体外影响。两种激素均采用酶联免疫吸附测定法进行定量。
结果
结果显示，白细胞介素-17在6小时（P < 0.001）和24小时（P < 0.01）时显著增加孕酮分泌，而这种细胞因子对hCG分泌没有影响。
结论
白细胞介素-17可能通过增加孕酮分泌来调节JEG - 3细胞的功能。
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