Discipline of Obstetrics and Gynecology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Optics and Imaging Centre, University of KwaZulu-Natal, Durban, South Africa.
Infect Dis Obstet Gynecol. 2020 May 30;2020:3417632. doi: 10.1155/2020/3417632. eCollection 2020.
Interleukin 17A has been implicated in the pathophysiology of both human immune deficiency virus and preeclampsia. This study evaluated serum levels of IL-17A based on pregnancy type, gestational age, HIV status, and duration of HAART. . A sample size of 250 was analysed: normotensives ( = 150; N) and preeclamptics ( = 100; PE). Normotensives were further stratified into HIV negative ( = 90), HAART-acute ( = 30), and HAART-chronic ( = 30). The PE group was divided into early onset ( = 50; EOPE) and late onset ( = 50; LOPE). The EOPE and LOPE groups were subdivided into HIV negative ( = 30), HAART-acute ( = 10), and HAART-chronic ( = 10). Analysis of IL-17A was performed using a multiple Bio-Plex immunoassay method.
Pregnancy type: the levels of IL-17A were increased in PE compared to N ( = 0.0014). Gestational age: the levels of IL-17A were increased in EOPE compared to N group ( = 0.0113). A significant increase in the levels of IL-17A in LOPE compared to N was observed ( = 0.0063). HIV status: the levels of IL-17A were increased in PE compared to N ( = 0.0114) and in EOPE compared to N groups ( = 0.0071). HAART duration: the concentration of IL-17A was increased in HAART-chronic PE compared to N groups ( = 0.0062). There was also an increase in the levels of IL-17A in EOPE compared to N ( = 0.0029).
The study demonstrates that IL-17A is involved in the pathophysiology of PE and that in the presence of HIV infection, chronic HAART administration predisposes women to the development of EOPE.
白细胞介素 17A 已被牵连到人类免疫缺陷病毒和先兆子痫的病理生理学中。本研究根据妊娠类型、孕龄、HIV 状态和高效抗逆转录病毒治疗（HAART）持续时间评估了 IL-17A 的血清水平。分析了 250 名样本：正常血压者（=150；N）和先兆子痫患者（=100；PE）。正常血压者进一步分为 HIV 阴性（=90）、HAART-急性（=30）和 HAART-慢性（=30）。PE 组分为早发型（=50；EOPE）和晚发型（=50；LOPE）。EOPE 和 LOPE 组进一步分为 HIV 阴性（=30）、HAART-急性（=10）和 HAART-慢性（=10）。使用多重 Bio-Plex 免疫分析方法分析了 IL-17A。
妊娠类型：与 N 组相比，PE 组的 IL-17A 水平升高（=0.0014）。孕龄：与 N 组相比，EOPE 组的 IL-17A 水平升高（=0.0113）。与 N 组相比，LOPE 组的 IL-17A 水平显著升高（=0.0063）。HIV 状态：与 N 组相比，PE 组的 IL-17A 水平升高（=0.0114），与 N 组相比，EOPE 组的 IL-17A 水平升高（=0.0071）。HAART 持续时间：与 N 组相比，慢性 HAART 治疗的 PE 组中 IL-17A 浓度升高（=0.0062）。与 N 组相比，EOPE 组的 IL-17A 水平也升高（=0.0029）。
本研究表明，IL-17A 参与了 PE 的病理生理学，并且在存在 HIV 感染的情况下，慢性 HAART 给药使妇女易发生 EOPE。
