Lee Eiko, Emoto Masanori, Teramura Megumi, Tsuchikura Shoko, Ueno Hiroki, Shinohara Kayo, Morioka Tomoaki, Mori Katsuhito, Koyama Hidenori, Shoji Tetsuo, Okuno Yasuhisa, Inaba Masaaki, Nishizawa Yoshiki
Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
J Atheroscler Thromb. 2009 Mar;16(1):33-9. doi: 10.5551/jat.e605. Epub 2009 Mar 5.
The clinical implications of stiffness of the carotid artery (CA) have not been fully clarified in the prediction of coronary artery disease (CAD), although intima-media thickness (IMT) has been established as a surrogate marker. We examined the associations of stiffness parameter beta (ST) and IMT with concurrent CAD.
IMT and ST were measured by ultrasound in 439 nondiabetic subjects as a control and 1528 type 2 diabetic subjects (T2DM) with or without CAD in a cross-sectional study.
Both IMT and ST significantly increased with age and group category, in the order of control, T2DM without CAD, and T2DM with CAD (p<0.001). The area under the curve on ROC analysis of ST for concurrent CAD was comparable to that for IMT. On multivariate logistic regression analysis, High IMT (>or=1.30 mm) and High stiffness (>or=20.0) had significant odds ratios for concurrent CAD (2.205, p<0.001 and 1.548, p<0.05, respectively). The group with High IMT and High Stiffness exhibited a stronger multivariate odds ratio (3.115, p=0.0001).
ST and IMT are associated with CAD and exhibited significant odds ratios for CAD. Our findings suggest that the combination of IMT and ST is a useful marker of atherosclerosis.
尽管内膜中层厚度（IMT）已被确立为替代标志物，但颈动脉（CA）僵硬度在冠状动脉疾病（CAD）预测中的临床意义尚未完全阐明。我们研究了僵硬度参数β（ST）和IMT与并发CAD之间的关联。
在一项横断面研究中，通过超声对439名非糖尿病受试者作为对照组以及1528名患有或未患有CAD的2型糖尿病受试者（T2DM）测量IMT和ST。
IMT和ST均随年龄和组别显著增加，顺序为对照组、无CAD的T2DM组和有CAD的T2DM组（p<0.001）。ST对并发CAD的ROC分析曲线下面积与IMT相当。在多因素逻辑回归分析中，高IMT（≥1.30mm）和高僵硬度（≥20.0）对并发CAD具有显著的优势比（分别为2.205，p<0.001和1.548，p<0.05）。高IMT和高僵硬度组表现出更强的多因素优势比（3.115，p = 0.0001）。
ST和IMT与CAD相关，且对CAD具有显著的优势比。我们的研究结果表明，IMT和ST的组合是动脉粥样硬化的有用标志物。
