在2型糖尿病男性患者中，内脏脂肪过多与血管僵硬度的关联更为密切，而非血管厚度。
Visceral Adiposity is Preferentially Associated with Vascular Stiffness Rather than Thickness in Men with Type 2 Diabetes.
作者信息
Morigami Hirokazu, Morioka Tomoaki, Yamazaki Yuko, Imamura Satoshi, Numaguchi Ryutaro, Asada Mariko, Motoyama Koka, Mori Katsuhito, Fukumoto Shinya, Shoji Tetsuo, Emoto Masanori, Inaba Masaaki
机构信息
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine.
出版信息
J Atheroscler Thromb. 2016 Sep 1;23(9):1067-79. doi: 10.5551/jat.33399. Epub 2016 Mar 5.
AIM
Visceral fat accumulation is known to underlie the clustering of cardiovascular risk factors. However, it is not completely understood how visceral fat accumulation influences the development of cardiovascular disease. In this study, we investigated the clinical impact of visceral adiposity on vascular stiffness and thickness in patients with type 2 diabetes (T2D).
METHODS
One hundred and sixty-one patients with T2D, including 92 men and 69 women, were included in this cross-sectional study. Visceral fat area (VFA) and subcutaneous fat area (SFA) were measured by dual bioelectrical impedance analysis. Stiffness parameter β and intima-media thickness (IMT) of the common carotid artery were measured by ultrasonography.
RESULTS
The mean age and duration of diabetes in the study population were 61 years and 13.9 years, respectively. In men, VFA and waist circumference (WC) were positively correlated with stiffness parameter β, whereas body mass index (BMI), WC, and SFA were negatively correlated with IMT. In contrast, in women, none of the obesity-related indices were significantly correlated with stiffness parameter β or IMT. In multiple regression analyses, VFA as well as WC, BMI, and SFA were independently associated with stiffness parameter β after adjustment for age and other potential confounders in men but not in women. None of the obesity-related indices were independently associated with IMT for either sex.
CONCLUSION
In men with T2D, visceral adiposity is associated with carotid arterial stiffness but not thickness.
目的
已知内脏脂肪堆积是心血管危险因素聚集的基础。然而，内脏脂肪堆积如何影响心血管疾病的发展尚不完全清楚。在本研究中，我们调查了内脏肥胖对2型糖尿病（T2D）患者血管僵硬度和厚度的临床影响。
方法
本横断面研究纳入了161例T2D患者，包括92名男性和69名女性。通过双能生物电阻抗分析测量内脏脂肪面积（VFA）和皮下脂肪面积（SFA）。通过超声测量颈总动脉的僵硬度参数β和内膜中层厚度（IMT）。
结果
研究人群的平均年龄和糖尿病病程分别为61岁和13.9年。在男性中，VFA和腰围（WC）与僵硬度参数β呈正相关，而体重指数（BMI）、WC和SFA与IMT呈负相关。相比之下，在女性中，没有一个肥胖相关指标与僵硬度参数β或IMT显著相关。在多元回归分析中，在对年龄和其他潜在混杂因素进行调整后，VFA以及WC.BMI和SFA在男性中与僵硬度参数β独立相关，而在女性中则不然。肥胖相关指标在任何性别中均与IMT无独立相关性。
结论
在患有T2D的男性中，内脏肥胖与颈动脉僵硬度有关，但与厚度无关。
Zotero 插件