Schlake Thomas, Sick Stefanie
Max-Planck Institute of Immunobiology, Freiburg, Germany.
Cell Adh Migr. 2007 Jul-Sep;1(3):149-51. doi: 10.4161/cam.1.3.5073. Epub 2007 Jul 23.
Canonical WNT signals play an important role in hair follicle development. In addition to being crucial for epidermal appendage initiation, they control the interfollicular spacing pattern and contribute to the spatial orientation and largely parallel alignment of hair follicles. However, owing to the complexity of canonical WNT signalling and its interconnections with other pathways, many details of hair follicle formation await further clarification. Here, we discuss the recently suggested reaction-diffusion (RD) mechanism of spatial hair follicle arrangement in the light of yet unpublished data and conclusions. They clearly demonstrate that the observed hair follicle clustering in dickkopf (DKK) transgenic mice cannot be explained by any trivial process caused by protein overexpression, thereby further supporting our model of hair follicle spacing. Furthermore, we suggest future experiments to challenge the RD model of spatial follicle arrangement.
经典WNT信号在毛囊发育中起重要作用。除了对表皮附属器的起始至关重要外，它们还控制毛囊间的间距模式，并有助于毛囊的空间定向和大致平行排列。然而，由于经典WNT信号传导的复杂性及其与其他途径的相互联系，毛囊形成的许多细节仍有待进一步阐明。在此，我们根据尚未发表的数据和结论，讨论最近提出的毛囊空间排列的反应扩散（RD）机制。这些数据清楚地表明，在dickkopf（DKK）转基因小鼠中观察到的毛囊聚集不能用蛋白质过表达引起的任何简单过程来解释，从而进一步支持了我们的毛囊间距模型。此外，我们建议进行未来的实验来挑战毛囊空间排列的RD模型。
