Doi Yasufumi, Ninomiya Toshiharu, Hata Jun, Yonemoto Koji, Tanizaki Yumihiro, Arima Hisatomi, Liu Ying, Rahman Mahbubur, Iida Misuo, Kiyohara Yutaka
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
J Epidemiol. 2009;19(2):56-62. doi: 10.2188/jea.je20080061. Epub 2009 Mar 6.
There have been few population-based studies of the seroprevalence and correlates of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in Japan.
We enrolled a total of 1244 adults, aged 18-59 years, from a population-based cohort in southern Japan, and tested their serum samples using an ELISA kit containing HSV type-specific antigens to glycoproteins G1 and G2.
The seroprevalence of HSV-1 and HSV-2 was 55.4% and 7.4% in men and 63.3% and 9.3% in women, respectively. Overall, 4 percent of the participants (2.3% of men and 5.0% of women) were co-infected with HSV-1 and HSV-2. The seroprevalences of both HSV-1 and HSV-2 increased with age in both sexes, and were always higher among women than among men in each age bracket. The prevalence of HSV-2 infection among HSV-1 infected individuals was lower than that among uninfected individuals, both in men and women. Male current drinkers, and male and female current smokers, were more likely to be infected with HSV-1 and HSV-2, as compared to never drinkers and never smokers, respectively.
It is hoped that the estimates produced in this study will help in understanding the burden of these infections in Japan.
在日本，基于人群的单纯疱疹病毒1型（HSV - 1）和2型（HSV - 2）血清流行率及其相关因素的研究较少。
我们从日本南部一个基于人群的队列中招募了总共1244名年龄在18 - 59岁的成年人，并使用一种包含HSV特异性糖蛋白G1和G2抗原的ELISA试剂盒检测他们的血清样本。
HSV - 1和HSV - 2的血清流行率在男性中分别为55.4%和7.4%，在女性中分别为63.3%和9.3%。总体而言，4%的参与者（男性为2.3%，女性为5.0%）同时感染了HSV - 1和HSV - 2。HSV - 1和HSV - 2的血清流行率在两性中均随年龄增长而升高，并且在每个年龄组中女性的流行率始终高于男性。在HSV - 1感染个体中，HSV - 2感染的患病率在男性和女性中均低于未感染个体。与从不饮酒者和从不吸烟者相比，男性当前饮酒者以及男性和女性当前吸烟者感染HSV - 1和HSV - 2的可能性更高。
希望本研究得出的估计值将有助于了解这些感染在日本造成的负担。
