College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Pediatric Infectious Disease, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Division of Pediatric Infectious Disease, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Molecular Infectious Disease Research Centre, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
PLoS One. 2015 Aug 7;10(8):e0134178. doi: 10.1371/journal.pone.0134178. eCollection 2015.
Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) are common human pathogens and might cause severe illness. Following primary infection, the viruses establish lifelong latent infection and are transmitted by close contact, both sexual and nonsexual. However, the information about the seroprevalence of HSV-1 and HSV-2 across all age groups is limited.
Residual sera collected during the nationwide serosurvey in 2007 in Taiwan were selected for the study. The enzyme-linked immunosorbent assay was used to detect anti-HSV-1 and anti-HSV-2 type-specific glycoprotein IgG. Demographics and personal health data were used for risk analysis.
A total of 1411 and 1072 serum samples were included for anti-HSV-1 and anti-HSV-2 seroprevalence analysis, respectively. The weighted overall seroprevalence was 63.2% for HSV-1, and 7.7% for HSV-2, respectively. The HSV-1 seropositive rate was 19.2% for those less than 5 years old, increased to 46.4% for those aged 5-13 years, 60.9% for those aged 14-29 years, and reached as much as 95.0% for those aged over 30 years. In contrast, the HSV-2 seropositve rate was 1.6% for those less than 30 years old, rose to 10.1% for those age 30-39 years, and was up to 31.2% for those aged over 60 years. A significantly higher HSV-2 seropositive rate was noted in females than males aged over 40 years (26.3% v.s. 16.8%), and the overall HSV-2 seropositive rate was almost twice higher in females than males. Smoking history, drinking habit, and educational level were associated with the HSV-1 seropositivity. Female gender and rural residence were independent factors for the HSV-2 seropositivity.
An obvious increase of primary HSV-1 infection occurred in late adolescents and young adults, joined by the rise of HSV-2 infection in middle-aged adults, especially females. The acquistion and transmission of HSV warrant further studies in the susceptible population.
单纯疱疹病毒 1 型（HSV-1）和 2 型（HSV-2）是常见的人类病原体，可能导致严重疾病。在初次感染后，病毒会建立终身潜伏感染，并通过密切接触传播，包括性接触和非性接触。然而，关于所有年龄段的 HSV-1 和 HSV-2 血清流行率的信息有限。
选择 2007 年台湾全国血清学调查期间收集的剩余血清进行研究。酶联免疫吸附试验用于检测抗 HSV-1 和抗 HSV-2 型特异性糖蛋白 IgG。使用人口统计学和个人健康数据进行风险分析。
共纳入 1411 份和 1072 份血清样本进行抗 HSV-1 和抗 HSV-2 血清流行率分析，分别。HSV-1 的加权总血清流行率为 63.2%，HSV-2 为 7.7%。5 岁以下儿童的 HSV-1 阳性率为 19.2%，5-13 岁儿童为 46.4%，14-29 岁儿童为 60.9%，30 岁以上儿童为 95.0%。相比之下，30 岁以下人群的 HSV-2 阳性率为 1.6%，30-39 岁人群为 10.1%，60 岁以上人群为 31.2%。40 岁以上女性的 HSV-2 阳性率明显高于男性（26.3%比 16.8%），女性的总 HSV-2 阳性率几乎是男性的两倍。吸烟史、饮酒习惯和教育程度与 HSV-1 阳性率相关。女性和农村居民是 HSV-2 阳性的独立因素。
青春期后期和年轻人中单纯疱疹病毒 1 型的原发感染明显增加，中年人群中单纯疱疹病毒 2 型的感染也有所增加，尤其是女性。在易感人群中，需要进一步研究单纯疱疹病毒的感染和传播。
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