Veldhoen Esther S, Hartman Barend J, van Gestel Josephus P J
Department of Pediatrics, The Pediatric Intensive Care Unit, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Pediatr Crit Care Med. 2009 Mar;10(2):e19-21. doi: 10.1097/PCC.0b013e3181956bda.
The aim of this report is to describe a fatal case of propofol infusion syndrome (PRIS), despite regular screening for this syndrome and immediate discontinuation of the infusion after the first signs of biochemical derangement.
Case report.
Pediatric intensive care unit.
A 17-year-old patient admitted after sustaining a traumatic brain injury.
Treatment for traumatic brain injury was given with mechanical ventilation, inotropic support, mannitol, and sedation with propofol. Blood gases and serum levels of lactate and creatine kinase were monitored frequently to screen for PRIS.
Propofol infusion was stopped immediately after the first signs of biochemical derangement. The patient died despite supportive treatment with intra-aortic balloon pump and cardiopulmonary resuscitation.
This case report demonstrates that frequent monitoring of biochemical parameters, as suggested in literature, cannot always prevent death due to PRIS.
本报告旨在描述一例丙泊酚输注综合征（PRIS）致死病例，尽管对该综合征进行了常规筛查，且在生化紊乱的最初迹象出现后立即停止了输注。
病例报告。
儿科重症监护病房。
一名17岁患者，因创伤性脑损伤入院。
对创伤性脑损伤进行治疗，包括机械通气、血管活性药物支持、甘露醇以及丙泊酚镇静。频繁监测血气、乳酸和肌酸激酶的血清水平以筛查PRIS。
在生化紊乱的最初迹象出现后立即停止丙泊酚输注。尽管采用主动脉内球囊泵支持治疗和心肺复苏，患者仍死亡。
本病例报告表明，如文献所建议的那样频繁监测生化参数，并不总能预防PRIS导致的死亡。
