特比萘芬与两性霉素B、氟伐他汀、利福平、甲硝唑及布洛芬联合对隐秘腐霉的体外活性
In vitro activity of terbinafine associated to amphotericin B, fluvastatin, rifampicin, metronidazole and ibuprofen against Pythium insidiosum.
作者信息
Cavalheiro Ayrton S, Zanette Régis A, Spader Tatiana B, Lovato Luciane, Azevedo Maria Isabel, Botton Sonia, Alves Sydney H, Santurio Janio M
机构信息
Departamento de Microbiologia e Parasitologia, Laboratório de Pesquisas Micológicas (LAPEMI), Universidade Federal de Santa Maria (UFSM), Avenida Roraima, 1000, Cidade Universitária, Bairro Camobi, Santa Maria-RS, 97105-900, Brazil.
出版信息
Vet Microbiol. 2009 Jun 12;137(3-4):408-11. doi: 10.1016/j.vetmic.2009.01.036. Epub 2009 Jan 31.
We evaluated the in vitro activities of terbinafine alone and in combination with amphotericin B, fluvastatin, rifampicin, metronidazole or ibuprofen against 17 clinical isolates of Pythium insidiosum. The assays were based on technique M38-A2, as well as the checkerboard microdilution method. The main synergism observed was by combination of terbinafine plus amphotericin B (41.18%). Antagonisms were observed in combinations of terbinafine with fluvastatin (35.30%) or rifampicin (5.88%).
我们评估了特比萘芬单独使用以及与两性霉素B、氟伐他汀、利福平、甲硝唑或布洛芬联合使用时，对17株隐秘腐霉临床分离株的体外活性。试验基于M38 - A2技术以及棋盘微量稀释法。观察到的主要协同作用是特比萘芬与两性霉素B联合使用时（41.18%）。在特比萘芬与氟伐他汀（35.30%）或利福平（5.88%）联合使用时观察到拮抗作用。
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