多梳蛋白复合体和三胸节复合体在CD4 T细胞记忆维持中的关键作用。
Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory.
作者信息
Nakayama Toshinori, Yamashita Masakatsu
机构信息
Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
出版信息
Semin Immunol. 2009 Apr;21(2):78-83. doi: 10.1016/j.smim.2009.02.001. Epub 2009 Mar 9.
The maintenance of memory CD4 T cells is crucial for the establishment of immunological memory. The Polycomb (PcG) and Trithorax group (TrxG) genes control key developmental regulators such as the homeobox genes, and these two antagonize each other in the same developmental processes. Recently, PcG gene Bmi1 has been found to control memory Th1/Th2 cell survival and TrxG gene MLL is to control the maintenance of memory Th2 cell function selectively. Therefore, in memory CD4 T cells, PcG and TrxG genes appear to control distinct processes in a distinct manner, which indicates a novel regulatory feature of the PcG/TrxG genes.
记忆性CD4 T细胞的维持对于免疫记忆的建立至关重要。多梳（PcG）基因和三胸节（TrxG）基因控制着关键的发育调节因子，如同源盒基因，并且这两类基因在相同的发育过程中相互拮抗。最近，已发现PcG基因Bmi1控制记忆性Th1/Th2细胞的存活，而TrxG基因MLL则选择性地控制记忆性Th2细胞功能的维持。因此，在记忆性CD4 T细胞中，PcG和TrxG基因似乎以不同的方式控制不同的过程，这表明了PcG/TrxG基因的一种新的调控特征。
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