Erren Thomas C, Morfeld Peter, Stork Joachim, Knauth Peter, von Mülmann Matthias J A, Breitstadt Rolf, Müller Uta, Emmerich Michael, Piekarski Claus
Institute and Policlinic for Occupational and Social Medicine, School of Medicine and Dentistry, University of Cologne, Kerpener Str. 62, 50937 Köln, Germany.
Scand J Work Environ Health. 2009 Jan;35(1):74-9. doi: 10.5271/sjweh.1303.
In October of 2007, an IARC panel of 24 scientists systematically evaluated epidemiologic, experimental, and mechanistic data and concluded that shift work that involves circadian or chronodisruption is probably carcinogenic in humans. In view of the possible scope of the problem--shift work is widespread and unavoidable on one hand and breast cancer and prostate cancer, which may be causally associated with chronodisruption, are epidemic worldwide on the other--German representatives of science and occupational medicine discussed the experimental and epidemiologic background and possible implications of the challenge identified by the International Agency for Research on Cancer (IARC) at a colloquium in Cologne in September 2008. This overview summarizes the key ideas presented at the Cologne Colloquium and offers 10 theses concerning the need for targeted studies and the necessity to develop possible means of prevention.
2007年10月，一个由24名科学家组成的国际癌症研究机构（IARC）小组系统地评估了流行病学、实验和机制数据，并得出结论：涉及昼夜节律或时间紊乱的轮班工作可能对人类具有致癌性。鉴于该问题可能涉及的范围——一方面，轮班工作普遍存在且不可避免；另一方面，可能与时间紊乱存在因果关系的乳腺癌和前列腺癌在全球范围内流行——德国科学和职业医学代表于2008年9月在科隆的一次学术讨论会上讨论了实验和流行病学背景以及国际癌症研究机构（IARC）所确定挑战的可能影响。本综述总结了在科隆学术讨论会上提出的关键观点，并就开展针对性研究的必要性以及开发可能的预防手段提出了10条论点。
