Hubacek Jaroslav A, Pitha Jan, Adamkova Vera, Lanska Vera, Poledne Rudolf
Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Clin Chem Lab Med. 2009;47(4):387-90. doi: 10.1515/CCLM.2009.109.
Recently, the role of the FTO (fat mass and obesity associated) gene in obesity development was described in Western European, but not in Oceanic, cohorts. The objective of this study was to test the hypothesis that the FTO single nucleotide polymorphism (SNP) is associated with body mass index (BMI) in the Slavic population and to analyze if there could be sex-specific effects of the SNP on BMI, waist-to-hip ratio (WHR), and lipid parameters.
We analyzed three large population-based samples comprising the post-MONICA study (1191 males, 1368 females) and the 3PMFs study (908 females).
FTO rs17817449 SNP was related to BMI in males (p=0.014). In the females from both the post-MONICA and the 3PMFs study, FTO had no effect on BMI. Sub-analysis of females from the 3PMFs study demonstrated that FTO had an effect on BMI in postmenopausal females (p=0.035) but not in premenopausal females (follicle-stimulating hormone <40 U/L was used as marker of premenopausal status). WHR and lipid parameters were not associated with FTO in any of the analyzed groups.
These results suggest that the effect of FTO SNP rs17817449 may be, in some populations at least, restricted to males and postmenopausal females.
最近，在西欧人群中描述了FTO（肥胖相关）基因在肥胖发展中的作用，但在大洋洲人群中尚未有相关报道。本研究的目的是检验FTO单核苷酸多态性（SNP）与斯拉夫人群体重指数（BMI）相关的假设，并分析该SNP对BMI、腰臀比（WHR）和血脂参数是否存在性别特异性影响。
我们分析了三个基于人群的大样本，包括莫妮卡研究后样本（1191名男性，1368名女性）和3PMFs研究样本（908名女性）。
FTO rs17817449 SNP与男性的BMI相关（p = 0.014）。在莫妮卡研究后样本和3PMFs研究的女性中，FTO对BMI没有影响。对3PMFs研究女性的亚分析表明，FTO对绝经后女性的BMI有影响（p = 0.035），但对绝经前女性没有影响（促卵泡生成素<40 U/L被用作绝经前状态的标志物）。在任何分析组中WHR和血脂参数均与FTO无关。
这些结果表明，至少在某些人群中FTO SNP rs17817449的影响可能仅限于男性和绝经后女性。
