Department of Obstetrics and Gynecology, Motol University Hospital, Prague 5, Czech Republic.
Physiol Res. 2021 Jul 12;70(3):469-474. doi: 10.33549/physiolres.934566. Epub 2021 May 12.
Among unique cardiovascular risk factors in women are complications during pregnancy, including miscarriage. Important risk factor is also genetic background. One of powerful candidate genes for cardiovascular disease of atherosclerotic origin (aCVD) is gene for connexin 37 (Cx37) with strong gene-environment interaction including smoking status, that is also strong risk factor for complications in pregnancy including spontaneous abortion (SA). We analyzed association between SA and Cx37 gene polymorphism (1019C>T; Pro319Ser) in 547 fetuses and its potential interaction with smoking status of mothers. Using genetic analyses from women from general population as controls, ORs for T allele, found in our previous studies to be protective against aCVD, were calculated. T allele carriers (fetuses), had OR 0.91 (95 % CI 0.72-1.14) and no interaction with smoking was observed. In conclusion, no significant association between Cx37 polymorphism and SA was observed and no modifying effect of smoking status on this association was detected.
在女性特有的心血管危险因素中，包括流产在内的妊娠并发症。重要的危险因素还有遗传背景。一种强有力的候选基因是缝隙连接蛋白 37（Cx37），其与包括吸烟状况在内的基因-环境相互作用强烈，而吸烟状况也是妊娠并发症（包括自然流产）的强烈危险因素。我们分析了 547 例胎儿中 Cx37 基因（1019C>T；Pro319Ser）多态性与自然流产之间的关系及其与母亲吸烟状况的潜在相互作用。利用一般人群女性的遗传分析作为对照，计算了我们之前研究中发现对动脉粥样硬化性心血管疾病具有保护作用的 T 等位基因的比值比（OR）。携带 T 等位基因（胎儿）的 OR 为 0.91（95%可信区间为 0.72-1.14），未观察到与吸烟的相互作用。总之，未观察到 Cx37 多态性与自然流产之间存在显著关联，也未检测到吸烟状态对这种关联的修饰作用。
