FTO基因rs9939609位点与MC4R基因rs17782313位点在中国汉族人群中对夜间血压升高的联合作用。
Combined effects of FTO rs9939609 and MC4R rs17782313 on elevated nocturnal blood pressure in the Chinese Han population.
作者信息
Sun Yanlei, Sun Jiazhong, Wu Jun, Yang Mei
机构信息
Department of Endocrinology, the Third Hospital of Wuhan, Wuhan, China, 430060.
Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, China, 430071.
出版信息
Cardiovasc J Afr. 2016 Jan-Feb;27(1):21-4. doi: 10.5830/CVJA-2015-064. Epub 2015 Aug 31.
AIM
In this study we investigated the association of FTO rs9939609 and MC4R rs17782313 with elevated blood pressure in the Chinese Han population, and analysed the relationship between the rs9939609 and rs17782313 variants.
METHODS
We tested the rs9939609 and rs17782313 variants with the sequence-retrieval method.
RESULTS
The increase in odds ratios of the A allele of rs9939609 and the C allele of rs17782313 for nocturnal blood pressure were 1.37 and 1.69. The nocturnal blood pressure of participants simultaneously carrying the A and C alleles was significantly higher than the blood pressure of those carrying neither FTO nor MC4R risk alleles (p < 0.05), and that of the controls carrying only the A or C alleles (p < 0.05). No association between the FTO or MC4R genes with daytime hypertension was found in this Chinese population (p > 0.05).
CONCLUSION
Our data suggest that the rs9939609 and rs17782313 variants may be significantly associated with nocturnal but not daytime blood pressure levels and their combined effects were significant in this Chinese Han population.
目的
在本研究中，我们调查了FTO基因rs9939609和MC4R基因rs17782313与中国汉族人群血压升高之间的关联，并分析了rs9939609和rs17782313变异之间的关系。
方法
我们采用序列检索法检测rs9939609和rs17782313变异。
结果
rs9939609的A等位基因和rs17782313的C等位基因使夜间血压的比值比分别增加1.37和1.69。同时携带A和C等位基因的参与者的夜间血压显著高于既不携带FTO也不携带MC4R风险等位基因的参与者的血压（p<0.05），也高于仅携带A或C等位基因的对照组的血压（p<0.05）。在这个中国人群中，未发现FTO或MC4R基因与日间高血压之间存在关联（p>0.05）。
结论
我们的数据表明，rs9939609和rs17782313变异可能与夜间而非日间血压水平显著相关，并且它们的联合作用在这个中国汉族人群中具有显著性。
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