Smith Ken R, Mineau Geraldine P, Garibotti Gilda, Kerber Richard
University of Utah, Salt Lake City, Utah, United States.
Soc Sci Med. 2009 May;68(9):1649-58. doi: 10.1016/j.socscimed.2009.02.010. Epub 2009 Mar 9.
We examine how key early family circumstances affect mortality risks decades later. Early-life conditions are measured by parental mortality, parental fertility (e.g., offspring sibship size, parental age at offspring birth), religious upbringing, and parental socioeconomic status. Prior to these early-life conditions are familial and genetic factors that affect life span. Accordingly, we consider the role of parental and familial longevity on adult mortality risks. We analyze the large Utah Population Database which contains a vast amount of genealogical and other vital/health data that contain full life histories of individuals and hundreds of their relatives. To control for unobserved heterogeneity, we analyze sib-pair data for 12,000 sib-pairs using frailty models. We found modest effects of key childhood conditions (birth order, sibship size, parental religiosity, parental SES, and parental death in childhood). Our measures of familial aggregation of longevity were large and suggest an alternative view of early-life conditions.
我们研究了早期关键的家庭环境如何在几十年后影响死亡风险。早期生活状况通过父母死亡率、父母生育情况(如子女同胞数量、父母生育子女时的年龄)、宗教教养以及父母的社会经济地位来衡量。在这些早期生活状况之前是影响寿命的家族和遗传因素。因此,我们考虑父母和家族长寿对成人死亡风险的作用。我们分析了庞大的犹他州人口数据库,该数据库包含大量的家谱和其他重要/健康数据,这些数据包含了个人及其数百名亲属的完整生活史。为了控制未观察到的异质性,我们使用脆弱模型分析了12000对同胞的数据。我们发现关键童年状况(出生顺序、同胞数量、父母宗教信仰、父母社会经济地位以及童年时期父母死亡)的影响较小。我们对长寿家族聚集的测量结果很大,并提出了对早期生活状况的另一种看法。