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经历父母早亡的后代的生存情况:早期生活条件与晚年死亡率

Survival of offspring who experience early parental death: early life conditions and later-life mortality.

作者信息

Smith Ken R, Hanson Heidi A, Norton Maria C, Hollingshaus Michael S, Mineau Geraldine P

机构信息

Department of Family and Consumer Studies and Population Sciences, Huntsman Cancer Institute, 675 Arapeen Suite 200, University of Utah, Salt Lake City, UT 84112, USA.

Department of Family and Preventive Medicine and Population Sciences, Huntsman Cancer Institute, University of Utah, USA.

出版信息

Soc Sci Med. 2014 Oct;119:180-90. doi: 10.1016/j.socscimed.2013.11.054. Epub 2014 Jan 8.

DOI:10.1016/j.socscimed.2013.11.054
PMID:24530028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4087105/
Abstract

We examine the influences of a set of early life conditions (ELCs) on all-cause and cause-specific mortality among elderly individuals, with special attention to one of the most dramatic early events in a child's, adolescent's, or even young adult's life, the death of a parent. The foremost question is, once controlling for prevailing (and potentially confounding) conditions early in life (family history of longevity, paternal characteristics (SES, age at time of birth, sibship size, and religious affiliation)), is a parental death associated with enduring mortality risks after age 65? The years following parental death may initiate new circumstances through which the adverse effects of paternal death operate. Here we consider the offspring's marital status (whether married; whether and when widowed), adult socioeconomic status, fertility, and later life health status. Adult health status is based on the Charlson Co-Morbidity Index, a construct that summarizes nearly all serious illnesses afflicting older individuals that relies on Medicare data. The data are based on linkages between the Utah Population Database and Medicare claims that hold medical diagnoses data. We show that offspring whose parents died when they were children, but especially when they were adolescents/young adults, have modest but significant mortality risks after age 65. What are striking are the weak mediating influences of later-life comorbidities, marital status, fertility and adult socioeconomic status since controls for these do little to alter the overall association. No beneficial effects of the surviving parent's remarriage were detected. Overall, we show the persistence of the effects of early life loss on later-life mortality and indicate the difficulties in addressing challenges at young ages.

摘要

我们研究了一系列早期生活条件(ELC)对老年人全因死亡率和特定病因死亡率的影响,特别关注儿童、青少年甚至年轻成年人生活中最重大的早期事件之一——父母死亡。首要问题是,在控制了早期生活中普遍存在(且可能具有混杂性)的条件(长寿家族史、父亲特征(社会经济地位、出生时年龄、同胞数量和宗教信仰))之后,父母死亡是否与65岁以后持续的死亡风险相关?父母死亡后的几年可能引发新的情况,父亲死亡的不利影响通过这些情况发挥作用。在这里,我们考虑子女的婚姻状况(是否已婚;是否丧偶以及何时丧偶)、成年后的社会经济地位、生育情况和晚年健康状况。成年健康状况基于查尔森合并症指数,该指数总结了几乎所有困扰老年人的严重疾病,其数据来源于医疗保险数据。这些数据基于犹他州人口数据库与包含医疗诊断数据的医疗保险理赔记录之间的关联。我们发现,父母在其儿童时期死亡的子女,但尤其是在青少年/年轻成年时期父母死亡的子女,在65岁以后有适度但显著的死亡风险。引人注目的是,晚年合并症、婚姻状况、生育情况和成年社会经济地位的中介影响较弱,因为对这些因素的控制几乎无法改变总体关联。未发现幸存父母再婚有任何有益影响。总体而言,我们展示了早期生活丧失对晚年死亡率影响的持续性,并指出了应对年轻时挑战的困难。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a6/4087105/533771c68eb8/nihms555517f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a6/4087105/533771c68eb8/nihms555517f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a6/4087105/533771c68eb8/nihms555517f1.jpg

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