Chen Qi, Wang Jianhua, Shen Meixiao, Cai Chunyan, Li Jianhua, Cui Lele, Qu Jia, Lu Fan
School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China.
Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3159-63. doi: 10.1167/iovs.08-2794. Epub 2009 Mar 11.
To investigate tear meniscus volumes during short-term lens wear by soft contact lens (SCL) wearers with dryness symptoms.
Three groups of 20 subjects were recruited. Group 1 consisted of SCL wearers with self-reported dryness. Group 2 consisted of asymptomatic wearers. Group 3 was composed of asymptomatic non-lens wearers. Contact lenses were fitted on each eye, and both upper and lower tear menisci were imaged before lens insertion, immediately afterward, and 30 minutes later, using optical coherence tomography. Custom software was used to yield the tear meniscus area, and then the volumes were calculated based on eyelid length. Repeatability was tested 30 minutes after lens wear on two consecutive days.
There were no significant differences (P > 0.05) between the volumes measured at 30 minutes after lens insertion on 2 days. In addition, the repeatability between days was similar among the groups. The upper and lower meniscus volumes were significantly lower in group 1 than in either of the asymptomatic groups at baseline, immediately after insertion, and 30 minutes later (P < 0.05). The upper tear meniscus in group 3 was greater than in group 2 at all times (P < 0.05). The lower meniscus volume immediately after insertion was significantly higher in group 3, the inexperienced wearers, than in group 2 (P < 0.05); however, the volumes at baseline and 30 minutes later were similar to one another (P > 0.05).
Tear volumes in dry eye symptomatic wearers were lower than asymptomatic wearers at baseline and during lens wear, which may have contributed to the dryness.
研究有干眼症状的软性接触镜(SCL)佩戴者在短期佩戴镜片过程中的泪液半月皱襞体积。
招募了三组,每组20名受试者。第一组由自述有干眼症状的SCL佩戴者组成。第二组由无症状佩戴者组成。第三组由无症状的非镜片佩戴者组成。给每只眼睛佩戴隐形眼镜,在插入镜片前、插入后即刻以及30分钟后,使用光学相干断层扫描对上下泪液半月皱襞进行成像。使用定制软件得出泪液半月皱襞面积,然后根据眼睑长度计算体积。在连续两天佩戴镜片30分钟后测试重复性。
在插入镜片2天后30分钟时测量的体积之间无显著差异(P>0.05)。此外,各组之间不同日期的重复性相似。在基线、插入后即刻和30分钟后,第一组的上下半月皱襞体积显著低于任何一个无症状组(P<0.05)。第三组的上泪液半月皱襞在所有时间均大于第二组(P<0.05)。在插入后即刻,第三组(无经验佩戴者)的下半月皱襞体积显著高于第二组(P<0.05);然而,基线和30分钟后的体积彼此相似(P>0.05)。
干眼症状佩戴者在基线和佩戴镜片期间的泪液体积低于无症状佩戴者,这可能是导致干眼的原因。