环境条件对软性隐形眼镜佩戴者泪液动力学的影响。

Effect of environmental conditions on tear dynamics in soft contact lens wearers.

作者信息

Maruyama Kunio, Yokoi Norihiko, Takamata Akira, Kinoshita Shigeru

机构信息

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

出版信息

Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2563-8. doi: 10.1167/iovs.03-1185.

DOI:10.1167/iovs.03-1185

PMID:15277478

Abstract

PURPOSE

Dry eye symptoms are often associated with soft contact lens (SCL) wear and may be affected by environmental conditions. This study was conducted to determine the effects of temperature and humidity on the tear film in SCL wearers.

METHODS

All 11 enrolled subjects were males (mean age, 23.5 +/- 5.2 [SD] years), and all wore SCL daily. They were exposed in different sessions to four different conditions in an environmental chamber with the air temperature (AT) and relative humidity (RH) set at 5 degrees C/10% (AT/RH), 15 degrees C/20%, 25 degrees C/40%, or 35 degrees C/50%. Two different types of hydrogel SCL (SCL-a and SCL-b; water content 72.0% and 37.5%, respectively) were used. The meniscus tear volume was determined on a video meniscometer by measuring the tear meniscus radius (TMR) with and without SCL. The tear interference patterns on the contact lens (TIPCL) were classified into five grades (the higher the grade, the thinner the film). Using a video interferometer, the non-invasive tear film breakup time (NIBUT) was recorded with and without SCLs; ocular dryness was also scored with and without SCLs.

RESULTS

Under the environmental conditions examined, there were no significant differences in the TMR without or with SCL, regardless of their type. As AT and RH decreased, there was a significant increase in the TIPCL grade (CL-a: P = 0.042; CL-b: P = 0.002), a significant decrease in NIBUT (CL-a: P = 0.004; CL-b: P = 0.001), and a significant increase in the dryness score (without SCL P = 0.023; with CL-a P = 0.009; with CL-b P = 0.003). The dryness scores were higher with CL-a than CL-b (P = 0.011 at 15 degrees C/20%). Under identical experimental conditions, we observed no significant change in NIBUT in the absence of an SCL.

CONCLUSIONS

AT and RH apparently had no effect on the tear volume in the presence of SCLs. As AT and RH decreased, the tear film on the SCL became thinner, NIBUT became shorter, and dryness increased. Dryness was more pronounced in eyes with SCL of the higher water content.

摘要

目的

干眼症状常与软性接触镜（SCL）佩戴有关，且可能受环境条件影响。本研究旨在确定温度和湿度对SCL佩戴者泪膜的影响。

方法

所有11名入选受试者均为男性（平均年龄23.5±5.2[标准差]岁），均每日佩戴SCL。他们在不同时段于环境舱中暴露于四种不同条件下，空气温度（AT）和相对湿度（RH）分别设定为5℃/10%（AT/RH）、15℃/20%、25℃/40%或35℃/50%。使用了两种不同类型的水凝胶SCL（SCL-a和SCL-b；含水量分别为72.0%和37.5%）。通过视频测弯仪，在佩戴和不佩戴SCL的情况下测量泪液弯月面半径（TMR）来确定泪液弯月面体积。将接触镜上的泪液干涉图案（TIPCL）分为五个等级（等级越高，泪膜越薄）。使用视频干涉仪，记录佩戴和不佩戴SCL时的非侵入性泪膜破裂时间（NIBUT）；同时记录佩戴和不佩戴SCL时的眼干程度评分。

结果

在所研究的环境条件下，无论SCL类型如何，佩戴或不佩戴SCL时的TMR均无显著差异。随着AT和RH降低，TIPCL等级显著升高（CL-a：P = 0.042；CL-b：P = 0.002），NIBUT显著降低（CL-a：P = 0.004；CL-b：P = 0.001），眼干程度评分显著升高（不佩戴SCL时P = 0.023；佩戴CL-a时P = 0.009；佩戴CL-b时P = 0.003）。佩戴CL-a时的眼干程度评分高于CL-b（在15℃/20%时P = 0.011）。在相同实验条件下，未佩戴SCL时NIBUT无显著变化。