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山葡萄叶和茎中的芪类化合物及低聚芪类化合物及其细胞毒性活性。

Stilbenes and oligostilbenes from leaf and stem of Vitis amurensis and their cytotoxic activity.

作者信息

Ha Do Thi, Chen Quan Cheng, Hung Tran Manh, Youn Ui Joung, Ngoc Tran Minh, Thuong Phuong Thien, Kim Hong Jin, Seong Yeon Hee, Min Byung Sun, Bae Kihwan

机构信息

College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.

出版信息

Arch Pharm Res. 2009 Feb;32(2):177-83. doi: 10.1007/s12272-009-1132-2. Epub 2009 Mar 13.

DOI:10.1007/s12272-009-1132-2
PMID:19280145
Abstract

Chromatographic separation of the EtOAc fraction from the leaf and stem of Vitis amurensis led to the isolation of six oligostilbenoids (i.e., r-2-viniferin (1), trans-amurensin B (2), trans-epsilon-viniferin (3), gnetin H (4), amurensin G (5), (+)-ampelopsin A (8)) and four stilbenoids (i.e., trans-resveratrol (6), (+)-ampelopsin F (7), piceatannol (9), and trans-piceid (10)). The structures have been identified on the basis of spectroscopic evidence and physicochemical properties. The isolates were investigated for cytotoxic activity against three cancer cell lines in vitro using the MTT assay method. Amurensin G (5) and trans-resveratrol (6) showed significant cytotoxic activity against L1210, K562 and HTC116 cancer cell lines with IC(50) values ranging from 15.7 +/- 2.1 to 30.9 +/- 1.8 microM. (+)-Ampelopsin A (8) and trans-piceid (10) exhibited considerable cytotoxic activity against L1210 (IC(50) values of 30.6 +/- 4.1 and 28.7 +/- 2.81 microM, respectively) and K562 (IC(50) values of 38.6 +/- 0.82 and 24.6 +/- 0.76 microM, respectively). Gnetin H (4) showed only weak cytotoxic activity against L1210 with an IC(50) value of 40.1 +/- 4.23 microM. On the other hand, r-2-viniverin (1), trans-amurensin B (2), trans-epsilon-viniferin (3), (+)-ampelopsin F (7), and piceatannol (9) exhibited no activity on three cancer cell lines.

摘要

对山葡萄叶和茎的乙酸乙酯馏分进行色谱分离，得到了六种低聚芪类化合物（即r - 2 - 葡萄素（1）、反式白藜芦醇B（2）、反式ε - 葡萄素（3）、银杏黄素H（4）、白藜芦醇G（5）、（+） - 蛇葡萄素A（8））和四种芪类化合物（即反式白藜芦醇（6）、（+） - 蛇葡萄素F（7）、紫铆因（9）和反式白藜芦醇苷（10））。这些化合物的结构已通过光谱证据和物理化学性质得以鉴定。采用MTT法在体外研究了这些分离物对三种癌细胞系的细胞毒性活性。白藜芦醇G（5）和反式白藜芦醇（6）对L1210、K562和HTC116癌细胞系表现出显著的细胞毒性活性，IC50值范围为15.7±2.1至30.9±1.8微摩尔。（+） - 蛇葡萄素A（8）和反式白藜芦醇苷（10）对L1210（IC50值分别为30.6±4.1和28.7±2.81微摩尔）和K562（IC50值分别为38.6±0.82和24.6±0.76微摩尔）表现出相当的细胞毒性活性。银杏黄素H（4）仅对L1210表现出较弱的细胞毒性活性，IC50值为40.1±4.23微摩尔。另一方面，r - 2 - 葡萄素（1）、反式白藜芦醇B（2）、反式ε - 葡萄素（3）、（+） - 蛇葡萄素F（7）和紫铆因（9）对三种癌细胞系均无活性。

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