自评健康与认知能力之间关联的遗传和环境中介作用。
Genetic and environmental mediation of the associations between self-rated health and cognitive abilities.
作者信息
Svedberg Pia, Gatz Margaret, Pedersen Nancy L
机构信息
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
出版信息
Exp Aging Res. 2009 Apr-Jun;35(2):178-201. doi: 10.1080/03610730902720372.
Abstract
This study examined the relationship between self-rated health and cognitive abilities. First, the authors investigated whether common complex diseases mediate the associations between self-rated health and cognitive abilities. Slight evidence was found that associations between self-rated health and cognitive test scores were mediated by chronic diseases. Second, the authors explored the genetic and environmental mediation of these relationships using bivariate quantitative genetic analyses. In the younger age group (<67 years), associations between self-rated health and spatial reasoning and perceptual speed were mediated by both genetic and nonshared environmental factors. In the oldest age group (>or=67 years), associations between self-rated health and spatial reasoning, perceptual speed, and visual memory were entirely due to genetic factors.
摘要
本研究考察了自评健康状况与认知能力之间的关系。首先，作者调查了常见的复杂疾病是否介导了自评健康状况与认知能力之间的关联。发现有轻微证据表明，慢性病介导了自评健康状况与认知测试分数之间的关联。其次，作者使用双变量定量遗传分析探索了这些关系的遗传和环境介导因素。在较年轻的年龄组（<67岁）中，自评健康状况与空间推理和知觉速度之间的关联由遗传因素和非共享环境因素共同介导。在最年长的年龄组（≥67岁）中，自评健康状况与空间推理、知觉速度和视觉记忆之间的关联完全归因于遗传因素。
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