Department of Bioorganic Chemistry and Biopharmaceutics, University of Pisa, Pisa, Italy.
Drug Dev Ind Pharm. 2009 Aug;35(8):941-9. doi: 10.1080/03639040802713460.
Mucoadhesive polysaccharides may prolong the residence of ophthalmic drugs in precorneal area. In this article, the mucoadhesiveness of arabinogalactan, tamarind seed polysaccharide, hyaluronan, hydroxyethylcellulose is compared in vivo, by the polymer residence time in rabbit tear fluid, and in vitro, by the polymer-induced increase of viscosity of a mucin dispersion. Polymer residence is prolonged by increased viscosity but shortened by reflex tearing caused by excessive viscosity. Tamarind seed polysaccharide is the most effective in prolonging the residence of ketotifen and diclofenac in precorneal area; hence, it is the optimal eyedrop additive as it is mucoadhesive while not increasing viscosity excessively.
黏附性多糖可延长眼部药物在角膜前区的滞留时间。本文通过聚合物在兔泪液中的停留时间，以及通过聚合物增加黏蛋白分散体的黏度来比较阿拉伯半乳聚糖、罗望子多糖、透明质酸、羟乙基纤维素的黏附性。聚合物的停留时间通过增加黏度而延长，但由于黏度过大引起的反射性流泪而缩短。罗望子多糖可显著延长酮替芬和双氯芬酸在角膜前区的滞留时间，是最有效的延长眼部药物在角膜前区滞留时间的辅料，因为它具有黏附性而不会过度增加黏度。
