Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
J Nanobiotechnology. 2022 Aug 2;20(1):361. doi: 10.1186/s12951-022-01567-7.
Ocular drug delivery is one of the most challenging endeavors among the various available drug delivery systems. Despite having suitable drugs for the treatment of ophthalmic disease, we have not yet succeeded in achieving a proper drug delivery approach with the least adverse effects. Nanotechnology offers great opportunities to overwhelm the restrictions of common ocular delivery systems, including low therapeutic effects and adverse effects because of invasive surgery or systemic exposure. The present review is dedicated to highlighting and updating the recent achievements of nano-based technologies for ocular disease diagnosis and treatment. While further effort remains, the progress illustrated here might pave the way to new and very useful ocular nanomedicines.
眼部药物递送是各种可用药物递送系统中最具挑战性的领域之一。尽管有适合治疗眼部疾病的药物，但我们尚未成功实现具有最小不良反应的适当药物递送方法。纳米技术为克服常见眼部递送系统的限制提供了巨大的机会，包括由于侵入性手术或全身暴露而导致的低治疗效果和不良反应。本综述旨在强调和更新基于纳米技术的眼部疾病诊断和治疗的最新成果。虽然还需要进一步努力，但这里展示的进展可能为新的非常有用的眼部纳米药物铺平道路。
