Xiao Yu-Hong, Ma Sai, Chen Ji-Hua, Chai Zhi-Guo, Li Fang, Wang Ying-Jie
Department of Stomatology, Kunming General Hospital of PLA, Kunming 650032, China.
J Biomed Mater Res B Appl Biomater. 2009 Aug;90(2):813-7. doi: 10.1002/jbm.b.31350.
This study evaluated the antibacterial effect and microtensile bond strength of a resin-based adhesive containing an antibacterial monomer DMAE-CB (methacryloxylethyl cetyl dimethyl ammonium chloride). Cured specimens of 1, 2, and 3% DMAE-CB-containing Single Bond 2 (crosslinking monomer: Bis-GMA, dimethacrylates; functional monomer: HEMA) were prepared, and their antibacterial effects on Streptococcus mutans ATCC 25175 were investigated. Antibacterial property after 0, 30, 90, and 180 days of aging was also tested. Bonding ability of the experimental adhesive incorporating 3% DMAE-CB was evaluated by microtensile bond strength test. The cured experimental adhesive exhibited an inhibitory effect on S. mutans growth, and the adhesive containing 3% DMAE-CB showed higher antibacterial efficiency compared with those incorporating 1 or 2% anibacterial monomer. Antibacterial activities of the specimens lasted for at least 180 days. Microtensile bond strength test revealed that the bonding ability of the experimental adhesive was not significantly adversely affected by the incorporation of DMAE-CB. Therefore, dental adhesives with strong and long-lasting bacteriostatic property could be achieved by incorporating DMAE-CB without negatively influencing bonding ability.
本研究评估了一种含有抗菌单体DMAE-CB（甲基丙烯酰氧基乙基十六烷基二甲基氯化铵）的树脂基粘合剂的抗菌效果和微拉伸粘结强度。制备了含1%、2%和3% DMAE-CB的单键2型固化标本（交联单体：双酚A缩水甘油醚，二甲基丙烯酸酯；功能单体：甲基丙烯酸羟乙酯），并研究了它们对变形链球菌ATCC 25175的抗菌效果。还测试了老化0、30、90和180天后的抗菌性能。通过微拉伸粘结强度测试评估了含3% DMAE-CB的实验性粘合剂的粘结能力。固化后的实验性粘合剂对变形链球菌的生长具有抑制作用，与含1%或2%抗菌单体的粘合剂相比，含3% DMAE-CB的粘合剂显示出更高的抗菌效率。标本的抗菌活性持续至少180天。微拉伸粘结强度测试表明，加入DMAE-CB对实验性粘合剂的粘结能力没有显著不利影响。因此，通过加入DMAE-CB可以实现具有强大且持久抑菌性能的牙科粘合剂，而不会对粘结能力产生负面影响。
