[关于鼠疫耶尔森氏菌疫苗株EV株FII组分诱导的实验性中毒中脂质过氧化激活在血液流变学特性紊乱机制中的致病意义]
[On pathogenetic significance of activation of lipid peroxidation in the mechanisms of disturbance of blood rheologic properties in experimental intoxication induced by fraction FII of vaccinal EV strain of Y. pestis].
作者信息
Afanas'eva G A, Chesnokova N P
出版信息
Vestn Ross Akad Med Nauk. 2009(2):14-8.
PMID:19280983
Abstract
Changes of blood viscosity were induced by parenteral administration of fraction II of vaccinal EV strain of Y. pestis ("murine" toxin) to mice at doses equivalent to LD50 and LD25. The study revealed correlation between lipid peroxidation activity, severity of autointoxication, and integrated indices of blood theologic properties.
摘要
通过向小鼠腹腔注射鼠疫耶尔森氏菌疫苗EV株（“鼠”毒素）的II组分，剂量相当于半数致死量（LD50）和四分之一致死量（LD25），诱导血液粘度变化。该研究揭示了脂质过氧化活性、自身中毒严重程度与血液流变学特性综合指标之间的相关性。
Zotero 插件