Wong O, Whorton M D, Foliart D E, Ragland D
Applied Health Sciences, San Mateo, CA 94401.
Am J Ind Med. 1991;20(3):317-34. doi: 10.1002/ajim.4700200305.
The cohort consisted of 10,173 men who had worked for at least one year in jobs involving exposure to vinyl chloride prior to 1 January 1973. These men were employed at 37 plants in the U.S., belonging to 17 companies. Observation of the mortality experience of the cohort was updated from 31 December 1972 to 31 December 1982 (the study now covering 1942-1982). A total of 1,536 cohort members were identified as having died. The observed mortality, by cause, was compared with the expected based on U.S. mortality rates, standardized for age, race, and calendar time. Analyses by length of exposure, latency, age at first exposure, calendar year of first exposure, and type of products were performed. The study confirmed that the vinyl chloride workers experience a significant mortality excesses in angiosarcoma (15 deaths), cancer of the liver and biliary tract (SMR = 641), and cancer of the brain and other central nervous system (SMR = 180). In addition, the study also found a significant mortality excess in emphysema/chronic obstructive pulmonary disease (COPD) (SMR = 179). On the other hand, the study did not find any excess in either respiratory cancer or lymphatic and hematopoietic cancer. This study also found an increase in biliary tract cancers, independent from liver cancer.
该队列由10173名男性组成，他们在1973年1月1日前从事过至少一年涉及接触氯乙烯的工作。这些男性受雇于美国37家工厂，隶属于17家公司。对该队列死亡情况的观察从1972年12月31日更新至1982年12月31日（该研究现涵盖1942 - 1982年）。共有1536名队列成员被确认死亡。将按病因观察到的死亡率与基于美国死亡率、按年龄、种族和日历时间标准化后的预期死亡率进行比较。按接触时长、潜伏期、首次接触年龄、首次接触日历年份以及产品类型进行了分析。该研究证实，氯乙烯工人在血管肉瘤（15例死亡）、肝癌和胆管癌（标准化死亡比 = 641）以及脑和其他中枢神经系统癌症（标准化死亡比 = 180）方面的死亡率显著过高。此外，该研究还发现肺气肿 / 慢性阻塞性肺疾病（COPD）的死亡率显著过高（标准化死亡比 = 179）。另一方面，该研究未发现呼吸道癌症或淋巴及造血系统癌症有任何过高情况。这项研究还发现胆管癌增加，且独立于肝癌。
