Collingwood K W, Milcarek B I, Raabe G K
Mobil Medical Department, Mobil Corporation, Princeton, NJ 08543-1038.
Am J Ind Med. 1991;20(3):343-52. doi: 10.1002/ajim.4700200307.
This retrospective cohort mortality study examined 2,467 workers in lubrication products blending and packaging (B&P) operations at two refineries of Mobil Corporation between January 1, 1945 and December 31, 1978. Ninety-seven percent were male. Compared with U.S. males, there were significantly fewer deaths observed among males due to all causes, external causes, and diseases of the circulatory, respiratory, digestive, and genitourinary systems. Deaths observed from all cancer were fewer than expected, although not statistically significant. No statistically significant excess cause-specific mortality occurred at B&P facilities combined or separately. Nonsignificant increases in mortality were observed for cancers of the stomach, large intestine, prostate, the category of "other lymphatic tissue" cancer, and leukemia and aleukemia. Analyses demonstrated a statistically significant pattern of increasing SMR with employment duration for "other lymphatic tissue" cancer. Within the highest cumulative duration of employment category, the excess was confined to workers after 30 or more years since first employment. Although the interpretation of cancer mortality patterns is limited due to small numbers of deaths, the absence of associations with specific B&P departments is evidence against a causal interpretation.
这项回顾性队列死亡率研究调查了1945年1月1日至1978年12月31日期间,美孚公司两家炼油厂从事润滑产品调配和包装(B&P)作业的2467名工人。其中97%为男性。与美国男性相比,从事B&P作业的男性因各种原因、外部原因以及循环、呼吸、消化和泌尿生殖系统疾病导致的死亡人数明显较少。所有癌症导致的死亡人数低于预期,尽管无统计学意义。在B&P设施合并或单独分析时,未出现具有统计学意义的特定病因死亡率过高情况。观察到胃癌、大肠癌、前列腺癌、“其他淋巴组织”癌、白血病和非白血病的死亡率有不显著增加。分析表明,“其他淋巴组织”癌的标准化死亡比(SMR)随就业年限增加呈统计学显著上升趋势。在累计就业年限最高的类别中,超额死亡仅限于首次就业30年或更长时间后的工人。尽管由于死亡人数较少,对癌症死亡率模式的解释有限,但未发现与特定B&P部门有关联,这一证据不支持因果关系解释。