Bast A, Haenen G R, Doelman C J
Department of Pharmacochemistry, Vrije Universiteit, Amsterdam, The Netherlands.
Am J Med. 1991 Sep 30;91(3C):2S-13S. doi: 10.1016/0002-9343(91)90278-6.
Reactive oxygen species are regarded as merely pernicious. This is incorrect for they play a pivotal role in many physiologic reactions, such as cytochrome P450-mediated oxidations, regulation of the tone of smooth muscle, and killing of microorganisms. An imbalance in oxidant-antioxidant activity is involved in many free radical-mediated pathologies, e.g., ischemia-reperfusion and asthma. In an attempt to alleviate these pathologies with antioxidants, it should be noted that these compounds are neither specific nor mere antioxidants. Associated with antioxidant activity is a pro-oxidant action. In the development of new antioxidant therapies, the important question of how these drugs are incorporated in or commensurate with existing integrated physiologic radical-defense systems should be addressed.
活性氧物种仅仅被视为有害的。但这是不正确的，因为它们在许多生理反应中发挥着关键作用，例如细胞色素P450介导的氧化反应、平滑肌张力的调节以及微生物的杀灭。氧化-抗氧化活性的失衡涉及许多自由基介导的病理过程，如缺血再灌注和哮喘。在试图用抗氧化剂缓解这些病理过程时，应该注意到这些化合物既不是特异性的，也不仅仅是抗氧化剂。与抗氧化活性相关的是促氧化作用。在开发新的抗氧化疗法时，应该解决这些药物如何融入现有的综合生理自由基防御系统或与之相适应这一重要问题。
