Sies H
Institute für Physiologische Chemie I, Universität Düsseldorf, Federal Republic of Germany.
Am J Med. 1991 Sep 30;91(3C):31S-38S. doi: 10.1016/0002-9343(91)90281-2.
The occurrence of reactive oxygen species, known as pro-oxidants, is an attribute of normal aerobic life. The steady-state formation of pro-oxidants is balanced by a similar rate of their consumption by antioxidants that are enzymatic and/or nonenzymatic. "Oxidative stress" results from imbalance in this pro-oxidant-antioxidant equilibrium in favor of the pro-oxidants. A number of diseases are associated with oxidative stress, being the basis of antioxidant therapy. Current evidence in clinical research does not show unequivocal distinction between causal or associative relationships of pro-oxidants to the disease process.
活性氧物种（即促氧化剂）的产生是正常需氧生命的一个特征。促氧化剂的稳态形成与其被酶促和/或非酶促抗氧化剂消耗的相似速率保持平衡。“氧化应激”是由这种促氧化剂 - 抗氧化剂平衡向促氧化剂倾斜的失衡所导致的。许多疾病都与氧化应激有关，这也是抗氧化疗法的基础。临床研究的现有证据并未明确区分促氧化剂与疾病过程之间的因果关系或关联关系。
