从柿皮（柿树）中提取的化合物的药理活性。

Pharmacological activity of compounds extracted from persimmon peel (Diospyros kaki THUNB.).

作者信息

Fukai Satomi, Tanimoto Shinichi, Maeda Aki, Fukuda Hitomi, Okada Yoshiharu, Nomura Masato

机构信息

Graduate School of System Engineering, Program in Systems Engineering, Kinki University, Hiroshima, Japan.

出版信息

J Oleo Sci. 2009;58(4):213-9. doi: 10.5650/jos.58.213.

DOI:10.5650/jos.58.213

PMID:19282644

Abstract

Persimmon peels (Diospyros kaki THUNB.) are discarded during the production of dried fruit. The 2-methoxy-4-vinylphenol (8) which is component of persimmon peel had high antioxidant activity on the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging assay and SOD (superoxide dismutase) assay. And (8) had higher tyrosinase inhibiting activity than that of arbutin using both L-tyrosine and L-DOPA as substrates. In addition, tyrosinase inhibiting activity of synthesized 2-methoxy-4-vinylphenol glycoside (8a) was studied. (8a) had tyrosinase inhibiting activity, suggesting that (8a) has possibilities for ingredient of cosmetics that are possessed of whitening effect.

摘要

在柿子干生产过程中，柿子皮（柿科柿属植物）被丢弃。柿子皮的成分2-甲氧基-4-乙烯基苯酚（8）在DPPH（1,1-二苯基-2-苦基肼）自由基清除试验和超氧化物歧化酶（SOD）试验中具有较高的抗氧化活性。并且，以L-酪氨酸和L-多巴为底物时，（8）的酪氨酸酶抑制活性高于熊果苷。此外，还研究了合成的2-甲氧基-4-乙烯基苯酚糖苷（8a）的酪氨酸酶抑制活性。（8a）具有酪氨酸酶抑制活性，这表明（8a）有可能成为具有美白效果的化妆品成分。